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Biosynthesis of a Periodic Protein Containing 3-Thienylalanine: A Step Toward Genetically Engineered Conducting Polymers

Kothakota, Srinivas and Mason, Thomas L. and Tirrell, David A. and Fournier, Maurille J. (1995) Biosynthesis of a Periodic Protein Containing 3-Thienylalanine: A Step Toward Genetically Engineered Conducting Polymers. Journal of the American Chemical Society, 117 (1). pp. 536-537. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:KOTjacs1995

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Abstract

Protein engineering provides an approach to materials synthesis in which macromolecular architecture is subject to precise control. Proteins synthesized biologically from a genetic template by the protein synthesis machinery are monodisperse with respect to molecular weight, and they are stereochemically pure, as only L-amino acids are used. Chemical composition and sequence are controlled, as the covalent structure of the chain is encoded by the template messenger RNA. We reasoned that genetic engineering technology could be used to create conducting materials by incorporation of electroactive amino acids, which could subsequently be cross-linked (or grafted) to produce extended conjugated systems. The role of the protein backbone in such materials would be to control the spatial organization of the conducting layers or domains. We report here the successful synthesis of a recombinant protein containing 3-thienylalanine (3-TA, 1) in place of phenylalanine (2).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja00106a064DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja00106a064PublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1995 American Chemical Society. Received September 26, 1994. This work was supported by Contract No. DAAH04-93-G-0217 from the U.S. Army Research Office and by a grant (DMR-8914359) from the Polymers and Genetics Programs of the National Science Foundation. NMR spectra were recorded in the University of Massachusetts NMR Laboratory, which is supported by the NSF Materials Research Laboratory at the University.
Funders:
Funding AgencyGrant Number
Army Research Office (ARO)DAAH04-93-G-0217
NSFDMR-8914359
Issue or Number:1
Record Number:CaltechAUTHORS:KOTjacs1995
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:KOTjacs1995
Official Citation:Biosynthesis of a Periodic Protein Containing 3-Thienylalanine: A Step Toward Genetically Engineered Conducting Polymers Srinivas Kothakota, Thomas L. Mason, David A. Tirrell, and Maurille J. Fournier Journal of the American Chemical Society 1995 117 (1), 536-537
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53485
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:28 Jan 2015 20:59
Last Modified:03 Oct 2019 07:50

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