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Selective H^+-Dependent Release of Contents from Thymine-Labeled Phospholipid Vesicles by an Adenine-Labeled Polyelectrolyte

Molina Pinilla, Inmaculada and Bueno Martinez, Manuel and Tirrell, David A. (1994) Selective H^+-Dependent Release of Contents from Thymine-Labeled Phospholipid Vesicles by an Adenine-Labeled Polyelectrolyte. Macromolecules, 27 (10). pp. 2671-2674. ISSN 0024-9297. https://resolver.caltech.edu/CaltechAUTHORS:PINm1993

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Abstract

Copolymers bearing 5.6, 9, or 11.7 mol % of adenine residues were prepared by radical copolymerization of 2-ethylacrylic acid (EAA) and 9-[[2-(methacryloyloxy)ethoxy]methyl] adenine (MAAd). A double-chain surfactant with thymine in the headgroup was synthesized and used in mixtures with egg yolk phosphatidylcholine (EYPC) to prepare thymine-labeled unilamellar lipid vesicles. Analysis of the pH-dependent behavior of the copolymers revealed that release of contents could be effected from labeled vesicles in competitive experiments in which unlabeled vesicles remained intact. Selectivity was greatest for the 9 mol % copolymer and was reduced at either lower or higher levels of adenine labeling. The selective recognition of the labeled membranes is ascribed to interactions between polymer-bound adenine and surface-bound thymine functional groups.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ma00088a004DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ma00088a004PublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Alternate Title:Selective H+-Dependent Release of Contents from Thymine-Labeled Phospholipid Vesicles by an Adenine-Labeled Polyelectrolyte
Additional Information:© 1993 American Chemical Society. Received December 21, 1993; Revised Manuscript Received February 15, 1994. This work was supported by the NSF Materials Research Laboratory at the University of Massachusetts. Financial support by the Direccion General de Investigacion Cientifica y Tecnica for M.B.M. is gratefully acknowledged.
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NSFUNSPECIFIED
Direccion General de Investigacion Cientifica y TecnicaUNSPECIFIED
Issue or Number:10
Record Number:CaltechAUTHORS:PINm1993
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:PINm1993
Official Citation:Selective H+-Dependent Release of Contents from Thymine-Labeled Phospholipid Vesicles by an Adenine-Labeled Polyelectrolyte Inmaculada Molina Pinilla, Manuel Bueno Martinez, and David A. Tirrell Macromolecules 1994 27 (10), 2671-2674
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53491
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:27 Jan 2015 00:58
Last Modified:03 Oct 2019 07:50

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