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Synthesis of a genetically engineered repetitive polypeptide containing periodic selenomethionine residues

Dougherty, Michael J. and Kothakota, Srinivas and Mason, Thomas L. and Tirrell, David A. and Fournier, Maurille J. (1993) Synthesis of a genetically engineered repetitive polypeptide containing periodic selenomethionine residues. Macromolecules, 26 (7). pp. 1779-1781. ISSN 0024-9297. https://resolver.caltech.edu/CaltechAUTHORS:DOUm1993

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Abstract

Genetically engineered proteins will play an important role in materials science. Many natural proteins have excellent materials properties such as the silks, elastin, and collagen, and, in principle, both these and entirely new protein materials can be produced from artificial genes. Good early progress has been made in this direction, including the synthesis of repetitive proteins predicted to self-assemble into solid lamellae of defined thickness and surface function (refs 1 and 2 and references therein). While biological synthesis offers the materials scientist superior control over polymer chain architecture, including purity of sequence, size, and stereochemistry, its versatility is limited to the 20 amino acids that appear in natural proteins. Thus, an important aim for the future will be to expand the number of amino acids that can be utilized in protein biosynthesis. First efforts in this direction would logically start with amino acid analogs known to be incorporated during translation. We describe here the first genetic synthesis of a periodic protein material in which an amino acid analog, selenomethionine, completely replaces a natural amino acid.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ma00059a045DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ma00059a045PublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1993 American Chemical Society. Received November 11, 1992 ;Revised Manuscript Received January 7, 1993. This work was supported by a grant from the Polymer and Genetics programs of the National Science Foundation (DMR 8914359).
Funders:
Funding AgencyGrant Number
NSFDMR 8914359
Issue or Number:7
Record Number:CaltechAUTHORS:DOUm1993
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:DOUm1993
Official Citation:Synthesis of a genetically engineered repetitive polypeptide containing periodic selenomethionine residues Michael J. Dougherty, Srinivas Kothakota, Thomas L. Mason, David A. Tirrell, and Maurille J. Fournier Macromolecules 1993 26 (7), 1779-1781
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53496
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:27 Jan 2015 00:30
Last Modified:03 Oct 2019 07:50

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