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Biological synthesis of monodisperse derivatives of poly(α,L-glutamic acid): model rodlike polymers

Zhang, Guanghui and Fournier, Maurille J. and Mason, Thomas L. and Tirrell, David A. (1992) Biological synthesis of monodisperse derivatives of poly(α,L-glutamic acid): model rodlike polymers. Macromolecules, 25 (13). pp. 3601-3603. ISSN 0024-9297. https://resolver.caltech.edu/CaltechAUTHORS:ZHAm1992

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Abstract

Poly(α,L-glutamic acid) (PLGA) and its derivatives have played a central role in the physical chemistry and materials science of polymers. PLGA itself has been used in fundamental studies of the helix-coil transition and polyelectrolyte chemistry, and rodlike esters of PLGA-most notably poly(γ-benzyl α,L-glutamate) (PBLG)-have been shown to form liquid crystalline solutions and beautifully ordered monolayer films. The traditional synthetic route to PLGA and its esters involves the ring-opening polymerization of N-carboxy-α-amino acid anhydrides. This technique affords heterogeneous populations of chains characterized by relatively broad distributions of molecular weights, and subsequent conversion of PLGA esters to the parent acid can be accompanied by substantial racemization. The heterogeneity of the resulting products complicates the interpretation of their hydrodynamic, spectroscopic, and liquid crystalline behavior and limits the utility of these polymers in the design and synthesis of complex macromolecular architectures. We report herein a general biosynthetic route to monodisperse derivatives of PLGA, unique rodlike polymers. The method is illustrated by the synthesis of polymer 1.


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http://dx.doi.org/10.1021/ma00039a048DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ma00039a048PublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1992 American Chemical Society. Received March 23, 1992; Revised Manuscript Received April 28, 1992. This work was supported by grants from the Polymers and Genetics Programs of the National Science Foundation and by the NSF Materials Research Laboratory at the University of Massachusetts.
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Issue or Number:13
Record Number:CaltechAUTHORS:ZHAm1992
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:ZHAm1992
Official Citation:Biological synthesis of monodisperse derivatives of poly(.alpha.,L-glutamic acid): model rodlike polymers Guanghui Zhang, Maurille J. Fournier, Thomas L. Mason, and David A. Tirrell Macromolecules 1992 25 (13), 3601-3603
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53504
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:23 Jan 2015 23:58
Last Modified:03 Oct 2019 07:50

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