You, Hong and Tirrell, David A. (1991) Photoinduced, polyelectrolyte-driven release of contents of phosphatidylcholine bilayer vesicles. Journal of the American Chemical Society, 113 (10). pp. 4022-4023. ISSN 0002-7863. doi:10.1021/ja00010a071. https://resolver.caltech.edu/CaltechAUTHORS:YOUjacs1991
Full text is not posted in this repository. Consult Related URLs below.
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:YOUjacs1991
Abstract
We report herein a new approach to the photoinduced release of contents of lipid bilayer vesicles. The method builds on prior work from this laboratory, in which it was shown that adsorption of the hydrophobic polyelectrolyte poly(2-ethylacrylic acid) (PEAA, 1) on phosphatidylcholine (PC, 2) membranes causes conversion of the lipid from vesicular to mixed micellar form. The adsorption of PEAA and the attendant vesicle-to-micelle transition are driven by increasing proton concentration, such that PC vesicles that are resistant to leakage at pH 7.4 can be induced to release their contents rapidly and quantitatively upon mild acidification. In the work described herein, we have used 3,3’-dicarboxydiphenyliodonium salts (3) as water-soluble, photosensitive proton sources. Irradiation of vesicular PC suspensions prepared in dilute aqueous solutions of 1 and 3 results in rapid loss of vesicle contents.
| Item Type: | Article | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Related URLs: |
| |||||||||
| ORCID: |
| |||||||||
| Additional Information: | © 1991 American Chemical Society. Received January 18, 1991; Revised Manuscript Received March 18, 1991. This work was supported by US. Army Research Office Grant DAAL03-88-K-0038. | |||||||||
| Funders: |
| |||||||||
| Issue or Number: | 10 | |||||||||
| DOI: | 10.1021/ja00010a071 | |||||||||
| Record Number: | CaltechAUTHORS:YOUjacs1991 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:YOUjacs1991 | |||||||||
| Official Citation: | Photoinduced, polyelectrolyte-driven release of contents of phosphatidylcholine bilayer vesicles Hong You and David A. Tirrell Journal of the American Chemical Society 1991 113 (10), 4022-4023 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 53514 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Anne Hormann | |||||||||
| Deposited On: | 22 Jan 2015 22:47 | |||||||||
| Last Modified: | 10 Nov 2021 20:03 |
Repository Staff Only: item control page
