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Genetically directed syntheses of new polymeric materials: efficient expression of a monodisperse copolypeptide containing fourteen tandemly repeated -(AlaGly)_4ProGluGly- elements

Creel, Howard S. and Fournier, Maurille J. and Mason, Thomas L. and Tirrell, David A. (1991) Genetically directed syntheses of new polymeric materials: efficient expression of a monodisperse copolypeptide containing fourteen tandemly repeated -(AlaGly)_4ProGluGly- elements. Macromolecules, 24 (5). pp. 1213-1214. ISSN 0024-9297. https://resolver.caltech.edu/CaltechAUTHORS:CREm1991

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Abstract

The statistical nature of chemical polymerization processes ensures that the materials prepared by such methods will consist of mixtures of chains. In contrast, ribosomal catalysis of protein synthesis on messenger RNA templates affords homogeneous products in which chain length, sequence, and stereochemistry are subject to exquisite control. With the advent of recombinant DNA methods in the 1970s, it has become possible to exploit this control in a synthetic sense, Le., to create new, artificial polypeptides of predetermined structure. Given the diversity of functionality, sequence, conformation, and chain lengths that become accessible in this way, it appears certain that this approach will find important applications in polymer materials science.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ma00005a040DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ma00005a040PublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1991 American Chemical Society. Received October 5, 1990; Revised Manuscript Received November 30, 1990. We thank Dr. Joseph Cappello of Protein Polymer Technologies for the gift of p937.51 and for fruitful discussions regarding the gene construction described herein. This work was supported by a grant from the Polymers and Genetics Programs of the National Science Foundation (DMR 8914359) and by the NSF Materials Research Laboratory at the University of Massachusetts.
Funders:
Funding AgencyGrant Number
NSFDMR 8914359
Issue or Number:5
Record Number:CaltechAUTHORS:CREm1991
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:CREm1991
Official Citation:Genetically directed syntheses of new polymeric materials: efficient expression of a monodisperse copolypeptide containing fourteen tandemly repeated -(AlaGly)4ProGluGly- elements Howard S. Creel, Maurille J. Fournier, Thomas L. Mason, and David A. Tirrell Macromolecules 1991 24 (5), 1213-1214
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53518
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:22 Jan 2015 22:31
Last Modified:03 Oct 2019 07:50

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