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Magnetic resonance microscopy of embryonic cell lineages and movements

Jacobs, Russell E. and Fraser, Scott E. (1994) Magnetic resonance microscopy of embryonic cell lineages and movements. Science, 263 (5147). pp. 681-684. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150109-151941399

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Abstract

Key events in vertebrate embryogenesis are difficult to observe in many species. High-resolution magnetic resonance imaging was used to follow cell movements and lineages in developing frog embryos. A single cell was injected at the 16-cell stage with a contrast agent, based on the gadolinium chelate gadolinium-diethylenetriamine pentaacetic acid-dextran. The labeled progeny cells could be followed uniquely in three-dimensional magnetic resonance images, acquired from the embryo over several days. The results show that external ectodermal and internal mesodermal tissues extend at different rates during amphibian gastrulation and neurulation.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.7508143DOIArticle
http://www.sciencemag.org/content/263/5147/681PublisherArticle
http://www.jstor.org/stable/2883091JSTORArticle
ORCID:
AuthorORCID
Jacobs, Russell E.0000-0002-1382-8486
Fraser, Scott E.0000-0002-5377-0223
Additional Information:© 1994 American Association for the Advancement of Science. 27 August 1993; Accepted 24 November 1993. We thank Z. H. Cho, C. B. Ahn, and S. Juh for assistance in the initial phases of this project; and J. Shih, A. Collazo, and J. Ivins for comments on the manuscript. Supported by National Institutes of Health grant HD 25390, the Baxter Foundation, and a gift from the Monsanto-Searle Company.
Funders:
Funding AgencyGrant Number
NIHHD 25390
Baxter FoundationUNSPECIFIED
Monsanto-Searle CompanyUNSPECIFIED
Issue or Number:5147
Record Number:CaltechAUTHORS:20150109-151941399
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150109-151941399
Official Citation:Jacobs, R., & Fraser, S. (1994). Magnetic resonance microscopy of embryonic cell lineages and movements. Science, 263(5147), 681-684. doi: 10.1126/science.7508143
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53523
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:12 Jan 2015 20:47
Last Modified:03 Oct 2019 07:50

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