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Structural reorganization of phosphatidylcholine vesicle membranes by poly(2-ethylacrylic acid): influence of the molecular weight of the polymer

Schroeder, Ulrich K. O. and Tirrell, David A. (1989) Structural reorganization of phosphatidylcholine vesicle membranes by poly(2-ethylacrylic acid): influence of the molecular weight of the polymer. Macromolecules, 22 (2). pp. 765-769. ISSN 0024-9297. http://resolver.caltech.edu/CaltechAUTHORS:SCHRm1989

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Abstract

Three samples of poly(2-ethylacrylic acid) (PEAA) of different molecular weights (M_w = 164000, 43000, and 12000) were prepared by radical polymerization of 2-ethylacrylic acid in bulk. The conformational properties of the samples were determined and correlated with the pH-dependent structural reorganization observed in phosphatidylcholine vesicles suspended in the respective polymer solutions. In all experiments the sample of lowest molecular weight behaved differently from the other two: The cooperativity of the conformational transition was reduced and the transition midpoint was shifted to lower pH as compared to the samples of higher molecular weight. These effects of polymer molecular weight were reflected in the behavior of the vesicle-to-micelle transition observed upon acidification of aqueous mixtures of PEAA and dipalmitoylphosphatidylcholine.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ma00192a042DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ma00192a042PublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1989 American Chemical Society. Received March 22, 1988; Revised Manuscript Received March 25, 1988. This work was supported by a grant from the US. Army Research Office (DAAL03-88-K-0038) and by a Presidential Young Investigator Award of the National Science Foundation. Financial support by the Deutsche Forschungsgemeinschaft for one of the authors (U.K.O.S.) is gratefully acknowledged. Registry No. 1, 62607-09-4; 2, 2644-64-6.
Funders:
Funding AgencyGrant Number
Army Research Office (ARO)DAAL03-88-K-0038
NSFUNSPECIFIED
Deutsche Forschungsgemeinschaft (DFG)UNSPECIFIED
Record Number:CaltechAUTHORS:SCHRm1989
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:SCHRm1989
Official Citation:Structural reorganization of phosphatidylcholine vesicle membranes by poly(2-ethylacrylic acid): influence of the molecular weight of the polymer Ulrich K. O. Schroeder and David A. Tirrell Macromolecules 1989 22 (2), 765-769
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53533
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:11 Jan 2015 03:30
Last Modified:11 Jan 2015 03:30

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