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H+-induced release of contents of phosphatidylcholine vesicles bearing surface-bound polyelectrolyte chains

Maeda, Mizuo and Kumano, Atsushi and Tirrell, David A. (1988) H+-induced release of contents of phosphatidylcholine vesicles bearing surface-bound polyelectrolyte chains. Journal of the American Chemical Society, 110 (22). pp. 7455-7459. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:MAEjacs1988

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Abstract

A semisynthetic vesicular membrane was constructed by immobilization of a synthetic polyelectrolyte [poly(2-ethylacrylic acid)] on the surface of a phosphatidylcholine bilayer. Immobilization was accomplished via Michael addition of polymer-bound thiol functions to a reactive maleimide handle incorporated into the lipid membrane in the form of dimyristoyl-N-[ [4-(maleimidomethyl)cyclohexyl]carbonyl]phosphatidylethanolamine. Semisynthetic membranes prepared in this way are sensitive to hydrogen ion concentration and are subject to large variations in permeability with small changes in pH. Rapid and quantitative release of vesicle contents can be achieved by mild acidification within the physiological pH range.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja00230a028DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja00230a028PublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1988 American Chemical Society. Received February 8, 1988. This work was supported by a Presidential Young Investigator Award of the National Science Foundation (to D.A.T.) and by matching contributions from Air Products and Chemicals Co., Exxon Research and Engineering Co., General Electric Co., and Xerox Corp. We are grateful for leaves of absence granted by the University of Tokyo (to M.M.) and by the Japan Synthetic Rubber Co. (to A.K.).
Funders:
Funding AgencyGrant Number
NSFUNSPECIFIED
Air Products and Chemicals Inc.UNSPECIFIED
Exxon Research and Engineering Co.UNSPECIFIED
General ElectricUNSPECIFIED
Xerox CorporationUNSPECIFIED
Record Number:CaltechAUTHORS:MAEjacs1988
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:MAEjacs1988
Official Citation:H+-induced release of contents of phosphatidylcholine vesicles bearing surface-bound polyelectrolyte chains Mizuo Maeda, Atsushi Kumano, and David A. Tirrell Journal of the American Chemical Society 1988 110 (22), 7455-7459
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53536
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:11 Jan 2015 00:25
Last Modified:11 Jan 2015 00:25

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