Maeda, Mizuo and Kumano, Atsushi and Tirrell, David A. (1988) H+-induced release of contents of phosphatidylcholine vesicles bearing surface-bound polyelectrolyte chains. Journal of the American Chemical Society, 110 (22). pp. 7455-7459. ISSN 0002-7863. doi:10.1021/ja00230a028. https://resolver.caltech.edu/CaltechAUTHORS:MAEjacs1988
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Abstract
A semisynthetic vesicular membrane was constructed by immobilization of a synthetic polyelectrolyte [poly(2-ethylacrylic acid)] on the surface of a phosphatidylcholine bilayer. Immobilization was accomplished via Michael addition of polymer-bound thiol functions to a reactive maleimide handle incorporated into the lipid membrane in the form of dimyristoyl-N-[ [4-(maleimidomethyl)cyclohexyl]carbonyl]phosphatidylethanolamine. Semisynthetic membranes prepared in this way are sensitive to hydrogen ion concentration and are subject to large variations in permeability with small changes in pH. Rapid and quantitative release of vesicle contents can be achieved by mild acidification within the physiological pH range.
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| Additional Information: | © 1988 American Chemical Society. Received February 8, 1988. This work was supported by a Presidential Young Investigator Award of the National Science Foundation (to D.A.T.) and by matching contributions from Air Products and Chemicals Co., Exxon Research and Engineering Co., General Electric Co., and Xerox Corp. We are grateful for leaves of absence granted by the University of Tokyo (to M.M.) and by the Japan Synthetic Rubber Co. (to A.K.). | ||||||||||||
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| Issue or Number: | 22 | ||||||||||||
| DOI: | 10.1021/ja00230a028 | ||||||||||||
| Record Number: | CaltechAUTHORS:MAEjacs1988 | ||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:MAEjacs1988 | ||||||||||||
| Official Citation: | H+-induced release of contents of phosphatidylcholine vesicles bearing surface-bound polyelectrolyte chains Mizuo Maeda, Atsushi Kumano, and David A. Tirrell Journal of the American Chemical Society 1988 110 (22), 7455-7459 | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 53536 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | Anne Hormann | ||||||||||||
| Deposited On: | 11 Jan 2015 00:25 | ||||||||||||
| Last Modified: | 10 Nov 2021 20:03 |
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