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Interactions of synthetic polymers with cell membranes and model membrane systems. 11. Glucose-dependent disruption of phospholipid vesicle membranes

Devlin, Brian P. and Tirrell, David A. (1986) Interactions of synthetic polymers with cell membranes and model membrane systems. 11. Glucose-dependent disruption of phospholipid vesicle membranes. Macromolecules, 19 (9). pp. 2465-2466. ISSN 0024-9297. https://resolver.caltech.edu/CaltechAUTHORS:DEVm1986

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Abstract

Poly(α-ethylacrylic acid) (PEAA, 1) undergoes a conformational transition to a globular structure upon acidification of its aqueous solutions. The globular polymer [1] associates strongly with bilayer vesicles prepared from phosphatidylcholines and phosphatidylglycerols, with profound disruption of bilayer organization. The latter phenomenon allows the formulation of phospholipid vesicles that release their contents rapidly and quantitatively in response to small changes in environmental pH. We show herein that this process can be combined with enzymic generation of H^+ to produce vesicles sensitive to low concentrations of neutral organic solutes such as glucose.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ma00163a028DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ma00163a028PublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1986 American Chemical Society. Received June 10, 1986. This work was supported by a grant from the 3M Co. and by a Presidential Young Investigator Award of the National Science Foundation (to D.A.T.). Part 11 in the series "Interactions of Synthetic Polymers with Cell Membranes and Model Membrane Systems". For Part 10, see: Ramaswami, V.; Tirrell, D. A. J. Polym. Sci., Polym. Chem. Ed. 1986, 24, 241.
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Funding AgencyGrant Number
3MUNSPECIFIED
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Issue or Number:9
Record Number:CaltechAUTHORS:DEVm1986
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:DEVm1986
Official Citation:Interactions of synthetic polymers with cell membranes and model membrane systems. 11. Glucose-dependent disruption of phospholipid vesicle membranes Brian P. Devlin and David A. Tirrell Macromolecules 1986 19 (9), 2465-2466
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53598
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:22 Jan 2015 00:32
Last Modified:03 Oct 2019 07:51

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