Devlin, Brian P. and Tirrell, David A. (1986) Interactions of synthetic polymers with cell membranes and model membrane systems. 11. Glucose-dependent disruption of phospholipid vesicle membranes. Macromolecules, 19 (9). pp. 2465-2466. ISSN 0024-9297. doi:10.1021/ma00163a028. https://resolver.caltech.edu/CaltechAUTHORS:DEVm1986
Full text is not posted in this repository. Consult Related URLs below.
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:DEVm1986
Abstract
Poly(α-ethylacrylic acid) (PEAA, 1) undergoes a conformational transition to a globular structure upon acidification of its aqueous solutions. The globular polymer [1] associates strongly with bilayer vesicles prepared from phosphatidylcholines and phosphatidylglycerols, with profound disruption of bilayer organization. The latter phenomenon allows the formulation of phospholipid vesicles that release their contents rapidly and quantitatively in response to small changes in environmental pH. We show herein that this process can be combined with enzymic generation of H^+ to produce vesicles sensitive to low concentrations of neutral organic solutes such as glucose.
| Item Type: | Article | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Related URLs: |
| |||||||||
| ORCID: |
| |||||||||
| Additional Information: | © 1986 American Chemical Society. Received June 10, 1986. This work was supported by a grant from the 3M Co. and by a Presidential Young Investigator Award of the National Science Foundation (to D.A.T.). Part 11 in the series "Interactions of Synthetic Polymers with Cell Membranes and Model Membrane Systems". For Part 10, see: Ramaswami, V.; Tirrell, D. A. J. Polym. Sci., Polym. Chem. Ed. 1986, 24, 241. | |||||||||
| Funders: |
| |||||||||
| Issue or Number: | 9 | |||||||||
| DOI: | 10.1021/ma00163a028 | |||||||||
| Record Number: | CaltechAUTHORS:DEVm1986 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:DEVm1986 | |||||||||
| Official Citation: | Interactions of synthetic polymers with cell membranes and model membrane systems. 11. Glucose-dependent disruption of phospholipid vesicle membranes Brian P. Devlin and David A. Tirrell Macromolecules 1986 19 (9), 2465-2466 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 53598 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Anne Hormann | |||||||||
| Deposited On: | 22 Jan 2015 00:32 | |||||||||
| Last Modified: | 10 Nov 2021 20:04 |
Repository Staff Only: item control page
