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Erythrocyte Form of Spectrin in Cerebellum: Appearance at a Specific Stage in the Terminal Differentiation of Neurons

Lazarides, Elias and Nelson, W. James (1983) Erythrocyte Form of Spectrin in Cerebellum: Appearance at a Specific Stage in the Terminal Differentiation of Neurons. Science, 220 (4603). pp. 1295-1296. ISSN 0036-8075. doi:10.1126/science.6190228.

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Chicken cerebellum expresses a polypeptide antigenically and biochemically related to the alpha subunit of spectrin, an erythrocyte membrane-cytoskeletal protein. Most of this polypeptide is associated with a brain specific spectrin subunit, gamma-spectrin, and is localized in virtually all neuronal cell bodies and processes. Cerebellum also expresses polypeptides antigenically related to the beta subunits of erythrocyte spectrin and these are also found in association with cerebellar alpha-spectrin but are confined to the plasmalemma of the neuronal cell bodies. This suggests that there is a mechanism for segregating different spectrin complexes into distinct membrane domains within a single cell.

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Additional Information:© 1983 American Association for the Advancement of Science. Received 14 July 1983; accepted 14 October 1983. This work was supported by grants from the National Institutes of Health (GM-06965 and a research career development award to E.L.), the National Science Foundation and Muscular Dystrophy Association, and a Cancer Research Campaign fellowship from the International Union Against Cancer (to W.J.N.).
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Muscular Dystrophy AssociationUNSPECIFIED
International Union Against CancerUNSPECIFIED
Issue or Number:4603
Record Number:CaltechAUTHORS:20150113-090059150
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Official Citation:Erythrocyte and brain forms of spectrin in cerebellum: distinct membrane-cytoskeletal domains in neurons E Lazarides and WJ Nelson Science 17 June 1983: 220 (4603), 1295-1296. [DOI:10.1126/science.6190228]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53611
Deposited By: Tony Diaz
Deposited On:13 Jan 2015 17:26
Last Modified:10 Nov 2021 20:04

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