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Evidence for a Computational Distinction Between Proximal and Distal Neuronal Inhibition

Vu, Eric T. and Krasne, Franklin B. (1992) Evidence for a Computational Distinction Between Proximal and Distal Neuronal Inhibition. Science, 255 (5052). pp. 1710-1712. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150113-102809677

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Abstract

Most neurons have inhibitory synapses both "proximally" near the spike-initiating zone and "distally" on dendrites. Although distal inhibition is thought to be an adaptation for selective inhibition of particular dendritic branches, another important distinction exists between proximal and distal inhibition. Proximal inhibition can attenuate excitatory input absolutely so that no amount of excitation causes firing. Distal inhibition, however, inhibits relatively; any amount of it can be overcome by sufficient excitation. These properties are used as predicted in the circuit-mediating crayfish escape behavior. Many neuronal computations require relative inhibition. This could partly account for the ubiquity of distal inhibition.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1553559DOIArticle
http://www.sciencemag.org/content/255/5052/1710PublisherArticle
http://www.jstor.org/stable/2876642JSTORArticle
Additional Information:© 1992 American Association for the Advancement of Science. Received 11 October 1991; accepted 14 January 1992. We thank M. Konishi and C. Koch for discussion and T. Teshiba for technical assistance. Supported by a predoctoral NSF fellowship to E.T.V. and by National Institute of Neurological Diseases and Stroke grant NS-08108.
Funders:
Funding AgencyGrant Number
NSF Predoctoral Fellowship UNSPECIFIED
National Institute of Neurological Diseases and StrokeNS-08108
Issue or Number:5052
Record Number:CaltechAUTHORS:20150113-102809677
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150113-102809677
Official Citation:Evidence for a computational distinction between proximal and distal neuronal inhibition ET Vu and FB Krasne Science 27 March 1992: 255 (5052), 1710-1712. [DOI:10.1126/science.1553559]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53620
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Jan 2015 19:58
Last Modified:03 Oct 2019 07:51

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