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Expression of the thymus leukemia antigen in mouse intestinal epithelium

Hershberg, Robert and Eghtesady, Pirooz and Sydora, Beate and Brorson, Kurt A. and Cheroutre, Hilde and Modlin, Robert and Kronenberg, Mitchell (1990) Expression of the thymus leukemia antigen in mouse intestinal epithelium. Proceedings of the National Academy of Sciences of the United States of America, 87 (24). pp. 9727-9731. ISSN 0027-8424. PMCID PMC55246. doi:10.1073/pnas.87.24.9727.

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The Qa and Tla regions of the mouse major histocompatibility complex contain a series of genes encoding proteins with structural similarity to the class I transplantation antigens of the same complex. In contrast to the genes encoding the transplantation antigens, the Qa and Tla genes show very little polymorphism. Function(s) of the proteins encoded by the Qa and Tla loci remain an enigma. Recently, the protein products of the Qa and Tla loci, often referred to as class Ib major histocompatibility complex molecules, have been proposed to present antigen to γδ T cells. In mice, γδ T cells have been found concentrated in several epithelial barriers and in the skin; yet, expression of serologically detectable Tla antigens is believed restricted to thymocytes, activated T lymphocytes, and some T-cell leukemias. Here we report that luminal epithelial cells of the mouse small intestine express the thymus leukemia antigen (TLA). We also find that, unlike T cells in Peyer's patches, a significant fraction of intestinal epithelial lymphocytes also express TLA. RNA prepared from intestinal cells contains transcripts of the T18d gene, which encodes TLA. These data extend the known expression profile of TLA molecules to mature lymphocytes and to nonhematopoietic cells. These data also demonstrate the specific expression of TLA on antigen-presenting cells in a site enriched for T cells that express gamma delta T-cell antigen receptor.

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Additional Information:© 1990 National Academy of Sciences. Communicated by Ray D. Owen, August 29, 1990 (received for review July 23, 1990). We gratefully acknowledge the help of Philip Mixter in the preparation and conjugation of mAbs. We thank Ingrid Schmid and Helene Lyons-Swanson for invaluable advice with flow cytometry. We also appreciate the assistance of Robin Bonner in providing reagents for immunohistochemistry. This work was supported by National Institutes of Health Grant CA 45956, by Pilot Project Grants from the University of California at Los Angeles Inflammatory Bowel Disease Center, and by the American Cancer Society Grant IRG-131. R.H. was supported by Medical Scientist Training Program (MSTP) Grant GM 07198; P.E. was supported by MSTP Grant GM-08042, and H.C. was supported by Postdoctoral Training Grant CA 09056.
Funding AgencyGrant Number
NIHCA 45956
American Cancer SocietyIRG-131
NIHGM 07198
NIH Postdoctoral FellowshipCA 09056
Issue or Number:24
PubMed Central ID:PMC55246
Record Number:CaltechAUTHORS:20150113-145716804
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Official Citation:Hershberg, R., Eghtesady, P., Sydora, B., Brorson, K., Cheroutre, H., Modlin, R., & Kronenberg, M. (1990). Expression of the thymus leukemia antigen in mouse intestinal epithelium. Proceedings of the National Academy of Sciences, 87(24), 9727-9731.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53638
Deposited By: Jason Perez
Deposited On:14 Jan 2015 06:52
Last Modified:10 Nov 2021 20:04

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