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Interactions of synthetic polymers with cell membranes and model membrane systems. Part 6. Disruption of phospholipid packing by branched poly(ethylenimine) derivatives

Takigawa, Doreen Y. and Tirrell, David A. (1985) Interactions of synthetic polymers with cell membranes and model membrane systems. Part 6. Disruption of phospholipid packing by branched poly(ethylenimine) derivatives. Macromolecules, 18 (3). pp. 338-342. ISSN 0024-9297. https://resolver.caltech.edu/CaltechAUTHORS:TAKm1985

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Abstract

High-sensitivity differential scanning calorimetry was used to examine the phase transition behavior of mixtures of dipalmitoylphosphatidylcholine (DPPC) or dipalmitoylphosphatidylglycerol (DPPG) with linear or branched poly(ethylenimine) derivatives. Unmodified poly(ethylenimines), branched or linear, caused no observable change in the melting of DPPC. Both polymers broadened the DPPG melting endotherm and produced small changes in the melting temperature. Attachment of side chains 6-12 carbon atoms in length produced hydrophobic poly(ethylenimine) derivatives which bound strongly to DPPC with complete disruption of the multilamellar vesicle structure.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ma00145a006DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ma00145a006PublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1985 American Chemical Society. Received May 18, 1984. Part 6 in a series on Interactions of Synthetic Polymers with Cell Membranes and Model Membrane Systems. This work was supported by 3M, St. Paul, MN. D.A.T. acknowledges the support of the Alfred P. Sloan Foundation (for a research fellowship) and of Dr. Thomas T. Chiu of Dow Chemical Co. [for a gift of poly(2-ethyloxazoline)]. NMR spectra were recorded on a Bruker WM-300 spectrometer purchased with the aid of a grant from the National Institutes of Health (GM27390-01). The purchase of the calorimeter was assisted by the National Science Foundation (CHE 79-11206). Registry No. DPPC, 63-89-8: dipalmitoylphosphatidylglycerol, 4537-77-3.
Funders:
Funding AgencyGrant Number
3MUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
NIHGM27390-01
NSFCHE 79-11206
Issue or Number:3
Record Number:CaltechAUTHORS:TAKm1985
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:TAKm1985
Official Citation:Interactions of synthetic polymers with cell membranes and model membrane systems. Part 6. Disruption of phospholipid packing by branched poly(ethylenimine) derivatives Doreen Y. Takigawa and David A. Tirrell Macromolecules 1985 18 (3), 338-342
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53646
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:20 Jan 2015 18:26
Last Modified:03 Oct 2019 07:51

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