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pH-Dependent complexation of poly(acrylic acid) derivatives with phospholipid vesicle membranes

Seki, Kenji and Tirrell, David A. (1984) pH-Dependent complexation of poly(acrylic acid) derivatives with phospholipid vesicle membranes. Macromolecules, 17 (9). pp. 1692-1698. ISSN 0024-9297. doi:10.1021/ma00139a009.

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Poly(acrylic acid), poly(methacrylic acid), and poly(α-ethylacrylic acid) can be used to modify, in a pH-dependent manner, the properties of phospholipid vesicle membranes. Polymer-lipid complexation caw a decrease in the apparent cooperativity of the lipid melting transition. The "critical pH" for complexation may be controlled through variation of the chemical structure and the tacticity of the poly(carboxylic acid), It is suggested that an important driving force for complexation is provided by the formation of hydrogen bonds between un-ionized carboxyl groups of the polymer and the phosphodiester functions of the lipid surface.

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Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1984 American Chemical Society. Received September 19, 1983. Part 5 in the series "Interactions of Synthetic Polymers with Cell Membranes and Model Membrane Systems". We thank Professors S. D. Merajver, S. L. Regen, K. Sakan, and U. Suter for stimulating discussions. This work was supported by an Alfred P. Sloan Research Fellowship to D. A. Tirrell and by leave of absence from Idemitsu Kosan Co., Ltd., to K. Seki. NMR spectra were recorded on a Bruker WM-300 spectrometer that was purchased with the aid of a grant from the National Institutes of Health (Grant NIGMS-GM27390-01). Purchase of the calorimeter was assisted by a grant from the National Science Foundation (Grant CHE-79-11206).
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Alfred P. Sloan FoundationUNSPECIFIED
Issue or Number:9
Record Number:CaltechAUTHORS:SEKm1984
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Official Citation:pH-Dependent complexation of poly(acrylic acid) derivatives with phospholipid vesicle membranes Kenji Seki and David A. Tirrell Macromolecules 1984 17 (9), 1692-1698
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53647
Deposited By: Anne Hormann
Deposited On:20 Jan 2015 18:16
Last Modified:10 Nov 2021 20:05

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