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A Role for Endothelial NO Synthase in LTP Revealed by Adenovirus-Mediated Inhibition and Rescue

Kantor, David B. and Lanzrein, Markus and Stary, S. Jennifer and Sandoval, Gisela M. and Smith, W. Bryan and Sullivan, Brian M. and Davidson, Norman and Schuman, Erin M. (1996) A Role for Endothelial NO Synthase in LTP Revealed by Adenovirus-Mediated Inhibition and Rescue. Science, 274 (5293). pp. 1744-1748. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150113-161505157

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Abstract

Pharmacological studies support the idea that nitric oxide (NO) serves as a retrograde messenger during long-term potentiation (LTP) in area CA1 of the hippocampus. Mice with a defective form of the gene for neuronal NO synthase (nNOS), however, exhibit normal LTP. The myristoyl protein endothelial NOS (eNOS) is present in the dendrites of CA1 neurons. Recombinant adenovirus vectors containing either a truncated eNOS (a putative dominant negative) or an eNOS fused to a transmembrane protein were used to demonstrate that membrane-targeted eNOS is required for LTP. The membrane localization of eNOS may optimally position the enzyme both to respond to Ca^(2+) influx and to release NO into the extracellular space during LTP induction.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.274.5293.1744DOIArticle
http://www.sciencemag.org/content/274/5293/1744PublisherArticle
http://www.jstor.org/stable/2890962JSTORArticle
Additional Information:© 1996 American Association for the Advancement of Science. 27 August 1996; Accepted 23 October 1996. We thank T. Michel for sharing various eNOS cDNAs and unpublished results, B. Seed for CD8 cDNA, A. Berk and L. Wu for Ad-lacZ, and G. Laurent for technical assistance and discussion. Supported by European Molecular Biology Organization grant ALTF 168-1996 (M.L.), National Institute of Mental Health grant 49176 (N.D.), NIH grant NS37292 (E.M.S.), and a Beckman Young Investigator award (E.M.S.)
Funders:
Funding AgencyGrant Number
European Molecular Biology OrganizationALTF 168-1996
National Institute of Mental Health (NIMH) 49176
NIHNS37292
Arnold and Mabel Beckman FoundationUNSPECIFIED
Issue or Number:5293
Record Number:CaltechAUTHORS:20150113-161505157
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150113-161505157
Official Citation:Kantor, D. B., Lanzrein, M., Stary, S. J., Sandoval, G. M., Smith, W. B., Sullivan, B. M., . . . Schuman, E. M. (1996). A Role for Endothelial NO Synthase in LTP Revealed by Adenovirus-Mediated Inhibition and Rescue. Science, 274(5293), 1744-1748. doi: 10.1126/science.274.5293.1744
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53660
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:14 Jan 2015 20:26
Last Modified:03 Oct 2019 07:51

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