CaltechAUTHORS
  A Caltech Library Service

Alternative splicing produces transcripts encoding two forms of the α subunit of GTP-binding protein G_o

Strathmann, Michael and Wilkie, Thomas M. and Simon, Melvin I. (1990) Alternative splicing produces transcripts encoding two forms of the α subunit of GTP-binding protein G_o. Proceedings of the National Academy of Sciences of the United States of America, 87 (17). pp. 6477-6481. ISSN 0027-8424. https://resolver.caltech.edu/CaltechAUTHORS:20150114-091407026

[img] PDF - Published Version
See Usage Policy.

1283Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20150114-091407026

Abstract

The α subunit of the guanine nucleotide-binding protein G_o ("o" for other) is believed to mediate signal transduction between a variety of receptors and effectors. cDNA clones encoding two forms of G_o α subunit were isolated from a mouse brain library. These two forms, which we call G_(o)Aα and G_(o)Bα, appear to be the products of alternative splicing. G_(o)Aα differs from G_(o)Bα over the C-terminal third of the deduced protein sequence. Both forms are predicted to be substrates for ADP-ribosylation by pertussis toxin. G_(o)Aα transcripts are present in a variety of tissues but are most abundant in brain. The G_(o)Bα transcript is expressed at highest levels in brain and testis. It is possible that G_(o)Aα and G_(o)Bα have different functions.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.pnas.org/content/87/17/6477PublisherArticle
Additional Information:© 1990 National Academy of Sciences. Contributed by Melvin I. Simon, June 4, 1990. We thank Carol Lee for technical assistance, Ryn Miake-Lye for RNA, Narasimhan Gautam for discussions, and T. H. Chang for critical reading of the manuscript. We are grateful to Y. Kaziro for communicating results before publication. This work was supported by National Institutes of Health Grant GM 34236.
Funders:
Funding AgencyGrant Number
NIHGM 34236
Issue or Number:17
Record Number:CaltechAUTHORS:20150114-091407026
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150114-091407026
Official Citation:Strathmann, M., Wilkie, T. M., & Simon, M. I. (1990). Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go. Proceedings of the National Academy of Sciences, 87(17), 6477-6481.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53672
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:15 Jan 2015 01:20
Last Modified:03 Oct 2019 07:51

Repository Staff Only: item control page