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Large-Scale and Automated DNA Sequence Determination

Hunkapiller, T. and Kaiser, R. J. and Koop, B. F. and Hood, L. (1991) Large-Scale and Automated DNA Sequence Determination. Science, 254 (5028). pp. 59-67. ISSN 0036-8075. doi:10.1126/science.1925562.

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DNA sequence analysis is a multistage process that includes the preparation of DNA, its fragmentation and base analysis, and the interpretation of the resulting sequence information. New technological advances have led to the automation of certain steps in this process and have raised the possibility of large-scale DNA sequencing efforts in the near future [for example, 1 million base pairs (Mb) per year]. New sequencing methodologies, fully automated instrumentation, and improvements in sequencing-related computational resources may render genome-size sequencing projects (100 Mb or larger) feasible during the next 5 to 10 years.

Item Type:Article
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Hood, L.0000-0001-7158-3678
Additional Information:© 1991 American Association for the Advancement of Science. 4 October 1991. We thank the NSF, DOE, NIH, and Alfred P. Sloan Foundation for support, Drs. D. Nickerson and J. R. Yates for careful reading of the manuscript, and K. McCarthy for help in preparing the manuscript.
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Department of Energy (DOE)UNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Issue or Number:5028
Record Number:CaltechAUTHORS:20150114-091754010
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Official Citation:Hunkapiller, T., Kaiser, R. J., Koop, B. F., & Hood, L. (1991). Large-Scale and Automated DNA Sequence Determination. Science, 254(5028), 59-67. doi: 10.2307/2879539
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53675
Deposited On:14 Jan 2015 23:44
Last Modified:10 Nov 2021 20:05

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