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Toward a Science of Metabolic Engineering

Bailey, James E. (1991) Toward a Science of Metabolic Engineering. Science, 252 (5013). pp. 1668-1675. ISSN 0036-8075. doi:10.1126/science.2047876.

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Application of recombinant DNA methods to restructure metabolic networks can improve production of metabolite and protein products by altering pathway distributions and rates. Recruitment of heterologous proteins enables extension of existing pathways to obtain new chemical products, alter posttranslational protein processing, and degrade recalcitrant wastes. Although some of the experimental and mathematical tools required for rational metabolic engineering are available, complex cellular responses to genetic perturbations can complicate predictive design.

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Additional Information:© 1991 American Association for the Advancement of Science. Supported by NSF and by the Catalysis and Biocatalysis Program of the Advanced Industrial Concepts Division of the U.S. Department of Energy. Advice and assistance in the preparation of this paper were provided by D. S. Clark, B. D. Ensley, T. Hashimoto, R. J. Kaufman, C. Khosla, R. A. Lazarus, A. J. Sinskey, K. N. Timmis, and colleagues at the California Institute of Technology.
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Department of Energy (DOE)UNSPECIFIED
Issue or Number:5013
Record Number:CaltechAUTHORS:20150114-105857007
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Official Citation:Toward a science of metabolic engineering JE Bailey Science 21 June 1991: 252 (5013), 1668-1675. [DOI:10.1126/science.2047876]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53705
Deposited By: Tony Diaz
Deposited On:14 Jan 2015 20:39
Last Modified:10 Nov 2021 20:05

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