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Characterization of poly(2-​ethylacrylic acid) for use in drug delivery

Linhardt, Jeffrey G. and Tirrell, David A. (2000) Characterization of poly(2-​ethylacrylic acid) for use in drug delivery. In: Controlled Drug Delivery: Designing Technologies for the Future. ACS Symposium Series. No.752. American Chemical Society , Washington, DC, pp. 243-252. ISBN 9780841236257. https://resolver.caltech.edu/CaltechAUTHORS:20150114-142433283

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Abstract

The pH-dependent conformational transition of poly(2-ethylacrylic acid) [PEAA] and its interaction with phosphotidylcholine bilayer membranes were investigated. The conformational transition was monitored with fluorescence spectroscopy using pyrene as a probe; the location and breadth of the conformational transition was shown to be dependent on the molecular weight and polydispersity of the sample, respectively. The pH-dependent destabilization and fusion of extruded large unilamellar vesicles (LWs) by PEAA was characterized by optical density measurements, transmission electron microscopy, and lipid mixing and contents release assays. Reduction of either the chain length or the polymer concentration caused the fusion and contents release events to shift to lower pH values. Release of entrapped calcein was observed at pH values ca. 1 unit higher than those found to cause membrane fusion. Decreased levels of fusion were observed when the concentration of PEAA was lower than that of the lipid; however, quantitative release of encapsulated calcein could be effected at very low polymer concentrations (-3% wlw PEAA/lipid).


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/bk-2000-0752.ch024DOIArticle
http://pubs.acs.org/doi/abs/10.1021/bk-2000-0752.ch024PublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Alternate Title:Utilizing the Hydrophobic Polyelectrolyte, Poly(2-Ethylacrylic Acid), for Drug Delivery
Additional Information:© 2000 American Chemical Society. This work was supported by a grant from INEX Pharmaceuticals, Inc.
Funders:
Funding AgencyGrant Number
INEX Pharmaceuticals, Inc.UNSPECIFIED
Series Name:ACS Symposium Series
Issue or Number:752
Record Number:CaltechAUTHORS:20150114-142433283
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150114-142433283
Official Citation:Characterization of Poly(2-ethylacrylic acid) for Use in Drug Delivery Jeffrey G. Linhardt and David A. Tirrell Controlled Drug Delivery. May 15, 2000, 243-252
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53733
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:16 Jan 2015 05:01
Last Modified:03 Oct 2019 07:52

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