Engineered Proteins in Materials Research

Abstract

Peptides and proteins have attracted scientific and technological interest largely because of their intriguing properties as catalysts, receptors, signalling molecules, and therapeutic agents. In attempts to understand and exploit these properties, protein engineering has been used primarily to obtain precious proteins in increased quantities, or to explore systematic alterations in protein sequence through site-directed mutagenesis. Design of protein structures de novo ("from scratch") has attracted less attention, and has been directed in the main toward studies of protein folding (Kamtekar et al., 1993). Such studies represent a key element in the current vigorous investigation of the connections between amino acid sequence and the three-dimensional structures of isolated protein chains in aqueous solution. This chapter describes protein engineering of quite another sort, in which the proteinacious nature of the product is less important than its macromolecular character.