Chen, Huijuan and Hsu, Shaw Ling and Tirrell, David A. and Stidham, Howard D. (1997) A pH Dependent Coil-to-Sheet Transition in a Periodic Artificial Protein Adsorbed at the Air-Water Interface. Langmuir, 13 (18). pp. 4775-4778. ISSN 0743-7463. doi:10.1021/la970207e. https://resolver.caltech.edu/CaltechAUTHORS:20150114-163429555
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Abstract
External infrared reflectance spectroscopy allows in situ determination of the conformational state of a periodic artificial protein adsorbed at the air−water interface. The protein, which consists of 36 copies of an octapeptide sequence [(AG)_3EG] constituted from alanine (A), glycine (G), and glutamic acid (E), adopts a random coil conformation in aqueous solution over a broad range of pH (5 < pH < 14). In contrast, the adsorbed chain undergoes a transition from a disordered (coil-like) state to a β-sheet conformation as the pH of the subphase is reduced. The conformational transition is offset by ca. 4 pH units from the titration curve of the polymer in aqueous solution, suggesting that the ionization behavior of the polymer is substantially perturbed by interfacial effects. In situ determination of the conformation of the adsorbed chain allows observation of a coil-to-sheet transition that is not observed in bulk solution.
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| Additional Information: | Copyright © 1997 American Chemical Society. Received February 25, 1997; Revised June 26, 1997. This work was supported by a grant from the Polymers and Genetics Program of the National Science Foundation (NSF) and by the NSF Materials Research Science and Engineering Center at the University of Massachusetts. | |||||||||
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| Issue or Number: | 18 | |||||||||
| DOI: | 10.1021/la970207e | |||||||||
| Record Number: | CaltechAUTHORS:20150114-163429555 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150114-163429555 | |||||||||
| Official Citation: | A pH Dependent Coil-to-Sheet Transition in a Periodic Artificial Protein Adsorbed at the Air−Water Interface Huijuan Chen, Shaw Ling Hsu, and David A. Tirrell, and Howard D. Stidham Langmuir 1997 13 (18), 4775-4778 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 53744 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Anne Hormann | |||||||||
| Deposited On: | 15 Jan 2015 02:37 | |||||||||
| Last Modified: | 10 Nov 2021 20:06 |
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