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Hierarchical sparse coding in the sensory system of Caenorhabditis elegans

Zaslaver, Alon and Liani, Idan and Shtangel, Oshrat and Ginzburg, Shira and Yee, Lisa and Sternberg, Paul W. (2015) Hierarchical sparse coding in the sensory system of Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America, 112 (4). pp. 1185-1189. ISSN 0027-8424. PMCID PMC4313814. https://resolver.caltech.edu/CaltechAUTHORS:20150115-102430590

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Abstract

Animals with compact sensory systems face an encoding problem where a small number of sensory neurons are required to encode information about its surrounding complex environment. Using Caenorhabditis elegans worms as a model, we ask how chemical stimuli are encoded by a small and highly connected sensory system. We first generated a comprehensive library of transgenic worms where each animal expresses a genetically encoded calcium indicator in individual sensory neurons. This library includes the vast majority of the sensory system in C. elegans. Imaging from individual sensory neurons while subjecting the worms to various stimuli allowed us to compile a comprehensive functional map of the sensory system at single neuron resolution. The functional map reveals that despite the dense wiring, chemosensory neurons represent the environment using sparse codes. Moreover, although anatomically closely connected, chemo- and mechano-sensory neurons are functionally segregated. In addition, the code is hierarchical, where few neurons participate in encoding multiple cues, whereas other sensory neurons are stimulus specific. This encoding strategy may have evolved to mitigate the constraints of a compact sensory system.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.1423656112DOIArticle
http://www.pnas.org/content/112/4/1185PublisherArticle
http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1423656112/-/DCSupplementalPublisherSupporting Information
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313814/PubMed CentralArticle
http://dx.doi.org/10.1073/pnas.1504344112DOIErratum
ORCID:
AuthorORCID
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 2015 National Academy of Sciences. Published ahead of print January 12, 2015. We thank Piali Sengupta for sharing the genetically ablated AWCON strain (PY7502). The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013) and European Research Council Grant Agreement 336803. Initial stages of this research were supported by the Caltech Center for Biological Circuit Design. P.W.S. is an investigator of the Howard Hughes Medical Institute, which supported this work. Author contributions: A.Z. and P.W.S. designed research; A.Z., I.L., O.S., S.G., and L.Y. performed research; A.Z. contributed new reagents/analytic tools; A.Z. analyzed data; and A.Z. and P.W.S. wrote the paper. The authors declare no conflict of interest. Freely available online through the PNAS open access option. This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1423656112/-/DCSupplemental.
Errata:Correction for Zaslaver et al., Hierarchical sparse coding in the sensory system of Caenorhabditis elegans PNAS 2015 112 (13) E1688-E1689; published ahead of print March 11, 2015, doi:10.1073/pnas.1504344112
Funders:
Funding AgencyGrant Number
European Research Council (ERC)336803
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:neural circuits; calcium imagaing; sensory coding
Issue or Number:4
PubMed Central ID:PMC4313814
Record Number:CaltechAUTHORS:20150115-102430590
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150115-102430590
Official Citation:Alon Zaslaver, Idan Liani, Oshrat Shtangel, Shira Ginzburg, Lisa Yee, and Paul W. Sternberg Hierarchical sparse coding in the sensory system of Caenorhabditis elegans PNAS 2015 112 (4) 1185-1189; published ahead of print January 12, 2015, doi:10.1073/pnas.1423656112
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53772
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Jan 2015 20:26
Last Modified:03 Oct 2019 07:52

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