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The elongation-termination decision in transcription

von Hippel, Peter H. and Yager, Thomas D. (1992) The elongation-termination decision in transcription. Science, 255 (5046). pp. 809-812. ISSN 0036-8075. doi:10.1126/science.1536005. https://resolver.caltech.edu/CaltechAUTHORS:20150115-143444800

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Abstract

At any template position, the decision to extend the transcript by one residue or to release the nascent RNA represents a kinetic competition between elongation and termination pathways. This competition is discussed in terms of alternative Eyring transition state barriers; changes in termination efficiency correspond to small changes in the relative heights of these barriers. Elongation complexes are stable at nonterminator positions; a model is presented to explain the destabilization of these complexes at intrinsic termination sites. Functionally analogous effects can operate at rho-dependent terminators. Mechanisms for modulation of termination efficiency by regulatory proteins are described.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1536005DOIArticle
http://www.sciencemag.org/content/255/5046/809PublisherArticle
http://www.jstor.org/stable/2876486JSTORArticle
Additional Information:© 1992 American Association for the Advancement of Science. We thank many colleagues for discussions and A. Das, C. Gross, and D. Jin for providing unpublished information. Supported in part by USPHS research grants GM-15792 and GM-29158 (to P.H.v.H.) and by a grant to the University of Oregon from the Lucille P. Markey Charitable Trust. P.H.v.H. is an American Cancer Society Research Professor of Chemistry.
Funders:
Funding AgencyGrant Number
United States Public Health Service (USPHS)GM-15792
United States Public Health Service (USPHS)GM-29158
Lucille P. Markey Charitable TrustUNSPECIFIED
Issue or Number:5046
DOI:10.1126/science.1536005
Record Number:CaltechAUTHORS:20150115-143444800
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150115-143444800
Official Citation:von Hippel, P., & Yager, T. (1992). The elongation-termination decision in transcription. Science, 255(5046), 809-812. doi: 10.1126/science.1536005
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53798
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:16 Jan 2015 18:21
Last Modified:10 Nov 2021 20:07

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