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Expression of the Major Neurofilament Subunit in Chicken Erythrocytes

Granger, Bruce L. and Lazarides, Elias (1983) Expression of the Major Neurofilament Subunit in Chicken Erythrocytes. Science, 221 (4610). pp. 553-556. ISSN 0036-8075. doi:10.1126/science.6346488.

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The 70,000-dalton core polypeptide of neurofilaments, thought to exist only in neurons, has been detected in chicken erythrocytes, where it coexists with vimentin and synemin as a component of the intermediate filament network. It is present in the circulating erythroid cells of embryos and young chickens but is nearly absent from the erythroid cells of adults. These findings are inconsistent with current models of intermediate filament expression, but provide another example of unexpected similarities between the nervous and hemopoietic systems.

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Additional Information:© 1983 American Association for the Advancement of Science. Received 4 March 1983. Supported by grants from the NIH [T32 GM07616 (B .G.), RCDA (E.L.), BRSG RR07003, and GM06965), NSF, and MDA. B.G. was also supported by a postdoctoral fellowship from the MDA. We thank W. J. Nelson, J. Ngai, R. D. Owen, and J.-P. Revel for critical reading of the manuscript.
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NIHT32 GM076165
Muscular Dystrophy AssociationUNSPECIFIED
Issue or Number:4610
Record Number:CaltechAUTHORS:20150116-141548264
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Official Citation:Expression of the major neurofilament subunit in chicken erythrocytes BL Granger and E Lazarides Science 5 August 1983: 221 (4610), 553-556. [DOI:10.1126/science.6346488]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53838
Deposited By: Tony Diaz
Deposited On:17 Jan 2015 03:18
Last Modified:10 Nov 2021 20:07

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