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Diversity of G proteins in signal transduction

Simon, Melvin I. and Strathmann, Michael P. and Gautam, Narasimhan (1991) Diversity of G proteins in signal transduction. Science, 252 (5007). pp. 802-808. ISSN 0036-8075. doi:10.1126/science.1902986.

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The heterotrimeric guanine nucleotide-binding proteins (G proteins) act as switches that regulate information processing circuits connecting cell surface receptors to a variety of effectors. The G proteins are present in all eukaryotic cells, and they control metabolic, humoral, neural, and developmental functions. More than a hundred different kinds of receptors and many different effectors have been described. The G proteins that coordinate receptor-effector activity are derived from a large gene family. At present, the family is known to contain at least sixteen different genes that encode the alpha subunit of the heterotrimer, four that encode beta subunits, and multiple genes encoding gamma subunits. Specific transient interactions between these components generate the pathways that modulate cellular responses to complex chemical signals.

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Additional Information:© 1991 American Association for the Advancement of Science.
Issue or Number:5007
Record Number:CaltechAUTHORS:20150120-101914277
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Official Citation:Simon, M., Strathmann, M., & Gautam, N. (1991). Diversity of G proteins in signal transduction. Science, 252(5007), 802-808. doi: 10.1126/science.1902986
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53868
Deposited On:20 Jan 2015 22:27
Last Modified:10 Nov 2021 20:08

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