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Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex

Montague, P. Read and Gancayco, Carolyn D. and Winn, Mark J. and Marchase, Richard B. and Friedlander, Michael J. (1994) Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex. Science, 263 (5149). pp. 973-977. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150121-092734339

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Abstract

L-Glutamate and norepinephrine are examples of a major excitatory neurotransmitter and a neuromodulator in the cerebral cortex, respectively. Little is known of how chemical signaling between the anatomically distinct chemical pathways occurs. Specific activation of the N-methyl-D-aspartate (NMDA) class of glutamate receptor in synaptosomal preparations from guinea pig cerebral cortex caused release of both of these chemicals, and this release was blocked by agents that inhibit nitric oxide (NO) production or remove NO from the extracellular space. Furthermore, neurotransmitter release correlated with cortical NO production after NMDA receptor stimulation. These results suggest that NO production and its extracellular movement may be links in the pathway from NMDA receptor activation to changes in chemical signaling in surrounding synaptic terminals in the cerebral cortex.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.7508638 DOIArticle
http://www.sciencemag.org/content/263/5149/973PublisherArticle
http://www.jstor.org/stable/2883276?origin=JSTOR-pdfJSTORArticle
Additional Information:© 1994 American Association for the Advancement of Science. 23 July 1993; accepted 4 January 1994. We thank F. Hester for luminometer measurements, J. Beckman for providing NO and help with its application and measurement, T. Sejnowski, J. Hablitz, S. Nowlan, and P. Dayan for helpful comments on an earlier draft of the manuscript, C. Stevens, M. Nusbaum, and J. Beckman for helpful discussions, J. Neville and L.A . Faulkner for word processing, K. Ramerf or figure preparation, and N. Veyna for synaptosome and luminometry protocols. Supported by NIH EY05116 (M.J.F.) and NIH EY06714 (R.B.M.).
Funders:
Funding AgencyGrant Number
NIHEY0511
NIHEY0671
Issue or Number:5149
Record Number:CaltechAUTHORS:20150121-092734339
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150121-092734339
Official Citation:Montague, P., Gancayco, C., Winn, M., Marchase, R., & Friedlander, M. (1994). Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex. Science, 263(5149), 973-977. doi: 10.1126/science.7508638
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53927
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:21 Jan 2015 23:23
Last Modified:03 Oct 2019 07:53

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