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Erythrocyte and Brain Forms of Spectrin in Cerebellum: Distinct Membrane-Cytoskeletal Domains in Neurons

Lazarides, Elias and Nelson, W. James (1983) Erythrocyte and Brain Forms of Spectrin in Cerebellum: Distinct Membrane-Cytoskeletal Domains in Neurons. Science, 220 (4603). pp. 1295-1296. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150121-093016381

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Abstract

Chicken cerebellum expresses a polypeptide antigenically and biochemically related to the alpha subunit of spectrin, an erythrocyte membrane-cytoskeletal protein. Most of this polypeptide is associated with a brain specific spectrin subunit, gamma-spectrin, and is localized in virtually all neuronal cell bodies and processes. Cerebellum also expresses polypeptides antigenically related to the beta subunits of erythrocyte spectrin and these are also found in association with cerebellar alpha-spectrin but are confined to the plasmalemma of the neuronal cell bodies. This suggests that there is a mechanism for segregating different spectrin complexes into distinct membrane domains within a single cell.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.6190228DOIArticle
http://www.sciencemag.org/content/220/4603/1295PublisherArticle
http://www.jstor.org/stable/1690401JSTORArticle
Additional Information:© 1983 American Association for the Advancement of Science. Received 28 February 1983; revised 1 April 1983. We thank Drs. K. Nakai and T. Kasamatsu for help in identifying the different neuronal cell types in the cerebellum and for performing the Nissl staining. Supported by NIH grant GM 06965, RCDA (E.L.), grants from the NSF and MDA, and an international fellowship (to W.J.N.) from the Cancer Research Campaign awarded by the International Union Against Cancer.
Funders:
Funding AgencyGrant Number
NIHGM 06965
RCDAUNSPECIFIED
NSFUNSPECIFIED
MDAUNSPECIFIED
International Union Against CancerUNSPECIFIED
Issue or Number:4603
Record Number:CaltechAUTHORS:20150121-093016381
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150121-093016381
Official Citation:Erythrocyte and brain forms of spectrin in cerebellum: distinct membrane-cytoskeletal domains in neurons E Lazarides and WJ Nelson Science 17 June 1983: 220 (4603), 1295-1296. [DOI:10.1126/science.6190228]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53929
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Jan 2015 20:49
Last Modified:03 Oct 2019 07:53

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