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Erythrocyte and Brain Forms of Spectrin in Cerebellum: Distinct Membrane-Cytoskeletal Domains in Neurons

Lazarides, Elias and Nelson, W. James (1983) Erythrocyte and Brain Forms of Spectrin in Cerebellum: Distinct Membrane-Cytoskeletal Domains in Neurons. Science, 220 (4603). pp. 1295-1296. ISSN 0036-8075. doi:10.1126/science.6190228.

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Chicken cerebellum expresses a polypeptide antigenically and biochemically related to the alpha subunit of spectrin, an erythrocyte membrane-cytoskeletal protein. Most of this polypeptide is associated with a brain specific spectrin subunit, gamma-spectrin, and is localized in virtually all neuronal cell bodies and processes. Cerebellum also expresses polypeptides antigenically related to the beta subunits of erythrocyte spectrin and these are also found in association with cerebellar alpha-spectrin but are confined to the plasmalemma of the neuronal cell bodies. This suggests that there is a mechanism for segregating different spectrin complexes into distinct membrane domains within a single cell.

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Additional Information:© 1983 American Association for the Advancement of Science. Received 28 February 1983; revised 1 April 1983. We thank Drs. K. Nakai and T. Kasamatsu for help in identifying the different neuronal cell types in the cerebellum and for performing the Nissl staining. Supported by NIH grant GM 06965, RCDA (E.L.), grants from the NSF and MDA, and an international fellowship (to W.J.N.) from the Cancer Research Campaign awarded by the International Union Against Cancer.
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NIHGM 06965
International Union Against CancerUNSPECIFIED
Issue or Number:4603
Record Number:CaltechAUTHORS:20150121-093016381
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Official Citation:Erythrocyte and brain forms of spectrin in cerebellum: distinct membrane-cytoskeletal domains in neurons E Lazarides and WJ Nelson Science 17 June 1983: 220 (4603), 1295-1296. [DOI:10.1126/science.6190228]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53929
Deposited By: Tony Diaz
Deposited On:21 Jan 2015 20:49
Last Modified:10 Nov 2021 20:25

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