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The evolution of bacterial mechanosensitive channels

Booth, Ian R. and Miller, Samantha and Müller, Axel and Lehtovirta-Morley, Laura (2015) The evolution of bacterial mechanosensitive channels. Cell Calcium, 57 (3). pp. 140-150. ISSN 0143-4160. http://resolver.caltech.edu/CaltechAUTHORS:20150121-095159810

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Abstract

Mechanosensitive channels are ubiquitous and highly studied. However, the evolution of the bacterial channels remains enigmatic. It can be argued that mechanosensitivity might be a feature of all membrane proteins with some becoming progressively less sensitive to membrane tension over the course of evolution. Bacteria and archaea exhibit two main classes of channels, MscS and MscL. Present day channels suggest that the evolution of MscL may be highly constrained, whereas MscS has undergone elaboration via gene fusion (and potentially gene fission) events to generate a diversity of channel structures. Some of these channel variants are constrained to a small number of genera or species. Some are only found in higher organisms. Only exceptionally have these diverse channels been investigated in any detail. In this review we consider both the processes that might have led to the evolved complexity but also some of the methods exploiting the explosion of genome sequences to understand (and/or track) their distribution. The role of MscS-related channels in calcium-mediated cell biology events is considered.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.ceca.2014.12.011DOIArticle
http://www.sciencedirect.com/science/article/pii/S0143416014002073PublisherArticle
Additional Information:© 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Received 30 November 2014; Received in revised form 16 December 2014; Accepted 17 December 2014; Available online 25 December 2014. IRB is funded by a Leverhulme Emeritus Research Fellowship and a CEMI research grant from Caltech. IRB and SM are funded by a WT Programme Grant (092552/A/10/Z). LL is funded by a NERC grant to Professors J.I. Prosser and G. Nicol (NE/I027835/1). AM is funded by a NIH Director's Pioneer Award (Grant 1DP1OD008304-01) to Bill Clemons (Caltech). The authors wish to thank Suzi Black, Jessica Ricci, Cai Neubauer, Megan Bergkessel, Dianne Newman, Rob Phillips, Doug Rees and Bill Clemons and other members of the Miller, Newman, Naismith and Conway labs for their stimulating conversations. IRB, SM and LL would like to thank Jim Prosser and Graeme Nicol (University of Aberdeen) for encouraging LL to take part in this project and Bill Clemons (Caltech) for the participation of AM. Conflict of interest: There are no known conflicts of interest.
Group:Caltech Center for Environmental Microbial Interactions (CEMI)
Funders:
Funding AgencyGrant Number
Leverhulme Emeritus Research FellowshipUNSPECIFIED
Caltech Center for Environmental Microbial Interactions (CEMI)UNSPECIFIED
WT Programme092552/A/10/Z
Natural Environment Research Council (NERC)NE/I027835/1
NIH Pioneer Award1DP1OD008304-01
Subject Keywords:Mechanosensitive channels; MscS; MscL; Gene synteny; Potassium channels
Record Number:CaltechAUTHORS:20150121-095159810
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150121-095159810
Official Citation:Ian R. Booth, Samantha Miller, Axel Müller, Laura Lehtovirta-Morley, The evolution of bacterial mechanosensitive channels, Cell Calcium, Volume 57, Issue 3, March 2015, Pages 140-150, ISSN 0143-4160, http://dx.doi.org/10.1016/j.ceca.2014.12.011. (http://www.sciencedirect.com/science/article/pii/S0143416014002073)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53935
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Jan 2015 20:45
Last Modified:20 Oct 2017 21:33

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