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Polyelectrolyte-sensitized phospholipid vesicles

Thomas, James L. and Tirrell, David A. (1992) Polyelectrolyte-sensitized phospholipid vesicles. Accounts of Chemical Research, 25 (8). pp. 336-342. ISSN 0001-4842. doi:10.1021/ar00020a003.

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Control of the structure and permeability of biological membranes is one of the most basic and least understood problems in contemporary biophysics. Diverse cellular processes require exquisite control of the membrane structure, including endocytosis and exocytosis, maintenance of the Golgi apparatus and the endoplasmic reticulum, and mitosis and meiosis, to mention just a few. Recently, significant progress has been made in controlling the permeability, and often the structures, of synthetic bilayer vesicles. These studies are especially important in that they help elucidate previously unimagined mechanisms for membrane control. Although no single model system is likely to utilize all of the rich capabilities exploited in nature, the synthetic systems can serve to identify concepts and mechanisms likely to be useful in a biological context. In addition, control of vesicular membrane systems may usher in novel chemistries for use in imaging, sensing, and therapeutic applications.

Item Type:Article
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Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1992 American Chemical Society. Publication Date: August 1992. Received January 29, 1992. We wish to acknowledge the assistance of Drs. Janos Fendler, Leaf Huang, Toyoki Kunitaki, David O’Brien, Demetrios Papahadjopoulos, Helmut Ringsdorf, Francis Szoka, and David Thompson, who provided reprints and preprints of their papers. Work in our own laboratories was supported by U. S. Army Research Office Grant DAAL03-88-K-0038 and by the 3M Corporation.
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Army Research Office (ARO)DAAL03-88-K-0038
Issue or Number:8
Record Number:CaltechAUTHORS:20150121-112329825
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Official Citation:Polyelectrolyte-sensitized phospholipid vesicles James L. Thomas and David A. Tirrell Accounts of Chemical Research 1992 25 (8), 336-342
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53943
Deposited By: Katherine Johnson
Deposited On:21 Jan 2015 19:32
Last Modified:10 Nov 2021 20:25

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