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The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes

Schoenherr, Christopher J. and Anderson, David J. (1995) The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science, 267 (5202). pp. 1360-1363. ISSN 0036-8075. doi:10.1126/science.7871435. https://resolver.caltech.edu/CaltechAUTHORS:20150121-121501631

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Abstract

The neuron-restrictive silencer factor (NRSF) binds a DNA sequence element, called the neuron-restrictive silencer element (NRSE), that represses neuronal gene transcription in nonneuronal cells. Consensus NRSEs have been identified in 18 neuron-specific genes. Complementary DNA clones encoding a functional fragment of NRSF were isolated and found to encode a novel protein containing eight noncanonical zinc fingers. Expression of NRSF mRNA was detected in most nonneuronal tissues at several developmental stages. In the nervous system, NRSF mRNA was detected in undifferentiated neuronal progenitors, but not in differentiated neurons. NRSF represents the first example of a vertebrate silencer protein that potentially regulates a large battery of cell type-specific genes, and therefore may function as a master negative regulator of neurogenesis.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.7871435DOIArticle
http://www.jstor.org/stable/2886006JSTORArticle
ORCID:
AuthorORCID
Anderson, David J.0000-0001-6175-3872
Additional Information:© 1995 American Association for the Advancement of Science. 31 October 1994: Accepted 1 February 1995. We thank T. Kadesch and P. Henthorn for cDNA libraries, N. Mori for HeLa nuclear extract, S. Padilla for technical assistance, S. Ou for antibody preparation, S. Tavtigian and B. Wold for cDNA libraries, L. Lo, A. Groves, and L. Banner for valuable advice M.-J. Fann and P. Patterson for actin probes, and B. Wold, L. Sommer, and S. Bultman for comments on the manuscript. Supported by NIH grant NS23476 and an Associate Investigatorship of the Howard Hughes Medical Institute (D.J.A.).
Funders:
Funding AgencyGrant Number
NIHNS23476
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:5202
DOI:10.1126/science.7871435
Record Number:CaltechAUTHORS:20150121-121501631
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150121-121501631
Official Citation:Schoenherr, C., & Anderson, D. (1995). The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science, 267(5202), 1360-1363. doi: 10.1126/science.7871435
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53947
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:21 Jan 2015 20:34
Last Modified:10 Nov 2021 20:25

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