A Caltech Library Service

Molecular Indices of Cell Lineage Specification in Sea Urchin Embryos

Angerer, Robert C. and Davidson, Eric H. (1984) Molecular Indices of Cell Lineage Specification in Sea Urchin Embryos. Science, 226 (4679). pp. 1153-1160. ISSN 0036-8075. doi:10.1126/science.6594757.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


The origins of several of the differentiated cell lineages of the advanced sea urchin embryo are well defined. Cytological application of molecular probes to three lineages, those responsible for the formation of the skeleton, the gut, and the aboral ectodermal wall of the late embryo, has demonstrated expression of lineage-specific genes long before overt morphological differentiation. These observations lead to useful generalizations regarding the processes of gene regulation that underlie the molecular biology of cell lineage specification in the embryo.

Item Type:Article
Related URLs:
URLURL TypeDescription
Additional Information:© 1984 American Association for the Advancement of Science. We would like to acknowledge our debt to the many colleagues who provided assistance in the preparation of this manuscript and the development of the ideas presented. We are particularly grateful to Professor David McClay of Duke University for making available original prints of his immunofluorescence experiments, for permission to reproduce them, for many stimulating conversations. Dr. Kathleen Cox was most cooperative in providing unpublished autoradiographs of the actin gene in situ hybridizations and Dr. Leonard Cohen kindly provided us the invaluable unpublished information regarding embryonic cell multiplication that is summarized in (13). Finally, we are most appreciative of the intelligent and critical commentary provided by Dr. Lynn Angerer, University of Rochester; Drs. Roy Britten, Frank Calzone, Norman Davidson, Barbara Hough-Evans, Elias Lazarides, Andrew McMahon, Ellen Rothenberg, and Barbara Wolde, California Institute of Technology; Dr. L. Dennis Smith, Purdue University; and Dr. Thoru Pederson, Worcester Foundation for Experimental Biology. Research was supported by NIH grants GM-25553 (R.C.A.) and HD-05753 (E.H.D.).
Funding AgencyGrant Number
Issue or Number:4679
Record Number:CaltechAUTHORS:20150121-131521079
Persistent URL:
Official Citation:Molecular indices of cell lineage specification in sea urchin embryos RC Angerer and EH Davidson Science 7 December 1984: 226 (4679), 1153-1160. [DOI:10.1126/science.6594757]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53953
Deposited By: Tony Diaz
Deposited On:21 Jan 2015 21:20
Last Modified:10 Nov 2021 20:25

Repository Staff Only: item control page