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Signal-Sensitive Release of Contents from Liposomes Bearing Surface-Grafted Polyelectrolyte Chains

Maeda, Mizuo and Kumano, Atsushi and Tirrell, David A. (1991) Signal-Sensitive Release of Contents from Liposomes Bearing Surface-Grafted Polyelectrolyte Chains. Annals of the New York Academy of Sciences, 618 (Temporal). pp. 362-366. ISSN 0077-8923. https://resolver.caltech.edu/CaltechAUTHORS:20150121-145328933

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Abstract

Therapeutic advantages of signal-sensitive drug delivery are easily imagined. Current dosage methods are most often empirically based, and only rarely reflect the actual time dependence of the patient's therapeutic need. In principle, self-regulated delivery systems would reduce the administered dose to a minimum while maintaining a therapeutically effective concentration of the agent at the target site. In practice, the routine application of self-regulated delivery systems remains relatively remote.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/j.1749-6632.1991.tb27256.xDOIArticle
http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1991.tb27256.x/abstractPublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1991 New York Academy of Sciences. Special Issue: Temporal Control of Drug Delivery. This work was supported in part by a grant from the U.S. Army Research Office (DAAL03–88-K-0038) and in part by a Presidential Young Investigator Award of the National Science Foundation (to D.A.T.).
Funders:
Funding AgencyGrant Number
Army Research Office (ARO)DAAL03–88-K-0038
NSFUNSPECIFIED
Issue or Number:Temporal
Record Number:CaltechAUTHORS:20150121-145328933
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150121-145328933
Official Citation:MAEDA, M., KUMANO, A. and TIRRELL, D. A. (1991), Signal-Sensitive Release of Contents from Liposomes Bearing Surface-Grafted Polyelectrolyte Chains. Annals of the New York Academy of Sciences, 618: 362–366. doi: 10.1111/j.1749-6632.1991.tb27256.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53961
Collection:CaltechAUTHORS
Deposited By: Katherine Johnson
Deposited On:21 Jan 2015 23:00
Last Modified:03 Oct 2019 07:54

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