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Recognition of tRNA Precursors: A Role for the Intron

Abelson, John (1992) Recognition of tRNA Precursors: A Role for the Intron. Science, 255 (5050). p. 1390. ISSN 0036-8075. doi:10.1126/science.1542787.

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Most eukaryotic genes contain introns that interrupt the continuity of the genetic information. Introns are removed from a precursor RNA transcript by a process called splicing, whereby the intron is clipped out and the exons are rejoined to give the functional RNA molecule. There are three distinct mechanisms of RNA splicing (1-3). In the self-splicing mechanism, discovered by Cech, the splicing process relies on the intron to take on a complex structure and to catalyze its own removal. In mRNA splicing in the eukaryotic nucleus, the pre-mRNA molecule is assembled into a large complex structure, the spliceosome, and components of the spliceosome, probably one or more of the small nuclear RNA's, catalyze the splicing reaction. In contrast, the small introns that interrupt the anticodon loops of eukaryotic precursor tRNA's are removed by a comparatively simple and familiar enzymatic process in which an endonuclease cleaves the two splice junctions and an ATP-dependent ligase joins the two exons.

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Additional Information:© 1992 American Association for the Advancement of Science.
Issue or Number:5050
Record Number:CaltechAUTHORS:20150122-133228464
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Official Citation:Recognition of tRNA Precursors: A Role for the Intron Author(s): John Abelson Source: Science, New Series, Vol. 255, No. 5050 (Mar. 13, 1992), p. 1390 Published by: American Association for the Advancement of Science Stable URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54001
Deposited On:23 Jan 2015 02:20
Last Modified:10 Nov 2021 20:26

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