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Genetic Networks

Loomis, William F. and Sternberg, Paul W. (1995) Genetic Networks. Science, 269 (5224). p. 649. ISSN 0036-8075. doi:10.1126/science.7624792. https://resolver.caltech.edu/CaltechAUTHORS:20150123-093352728

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Abstract

The interactions of biological macromolecules and the flow of regulatory information that controls development, behavior, and homeostasis can be considered a genetic network. The nodes in such networks are genes or their RNA and protein products. The connections are the regulatory and physical interactions among the RNAs, proteins, and cis-regulatory DNA sequences of each gene. Modem molecular genetic techniques have greatly increased the rate at which genes are being recognized and their primary sequences determined. The challenge is to link the genes and their products into functional pathways, circuits, and networks. Analyses of regulatory networks (such as those involving signal transduction and transcriptional regulation cascades) illustrate combinatorial action that implements, for example, digital logic, analog-digital conversions, cross-talk and insulation, and signal integration. Although the existence of sophisticated network elements has been suggested by decades of physiological studies, what is new is the scale and detail becoming available for the components. Much of current molecular biology focuses on identifying new components, defining the regulatory in puts and outputs of each node, and delineating the physiologically relevant pathways.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.jstor.org/stable/2888958JSTORArticle
http://dx.doi.org/10.1126/science.7624792DOIArticle
http://www.sciencemag.org/content/269/5224/649.citationPublisherArticle
ORCID:
AuthorORCID
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 1995 American Association for the Advancement of Science.
Issue or Number:5224
DOI:10.1126/science.7624792
Record Number:CaltechAUTHORS:20150123-093352728
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150123-093352728
Official Citation:Loomis, W. F., & Sternberg, P. W. (1995). Genetic Networks. Science, 269(5224), 649. doi: 10.1126/science.7624792
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54013
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:23 Jan 2015 22:28
Last Modified:10 Nov 2021 20:26

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