Kang, Hyejin and Schuman, Erin M. (1996) A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity. Science, 273 (5280). pp. 1402-1406. ISSN 0036-8075. doi:10.1126/science.273.5280.1402. https://resolver.caltech.edu/CaltechAUTHORS:20150123-093647592
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Abstract
Two neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are able to produce a long-lasting enhancement of synaptic transmission in the hippocampus. Unlike other forms of plasticity, neurotrophin-induced plasticity exhibited an immediate requirement for protein synthesis. Plasticity in rat hippocampal slices in which the synaptic neuropil was isolated from the principal cell bodies also required early protein synthesis. Thus, the neurotrophins may stimulate the synthesis of proteins in either axonal or dendritic compartments, allowing synapses to exert local control over the complement of proteins expressed at individual synaptic sites.
| Item Type: | Article | ||||||||||||
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| Additional Information: | © 1996 American Association for the Advancement of Science. 20 May 1996; accepted 16 July 1996. We thank J. Miller and Amgen for supplying BDNF and NT-3, and Caltech faculty and the Schuman lab for helpful discussions and comments. Supported by funds from the Sloan Foundation, John Merck Fund, and Pew Charitable Trusts to E.M.S. | ||||||||||||
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| Issue or Number: | 5280 | ||||||||||||
| DOI: | 10.1126/science.273.5280.1402 | ||||||||||||
| Record Number: | CaltechAUTHORS:20150123-093647592 | ||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150123-093647592 | ||||||||||||
| Official Citation: | Kang, H., & Schuman, E. M. (1996). A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity. Science, 273(5280), 1402-1406. doi: 10.1126/science.273.5280.1402 | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 54014 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | INVALID USER | ||||||||||||
| Deposited On: | 23 Jan 2015 20:06 | ||||||||||||
| Last Modified: | 10 Nov 2021 20:26 |
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