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A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity

Kang, Hyejin and Schuman, Erin M. (1996) A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity. Science, 273 (5280). pp. 1402-1406. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150123-093647592

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Abstract

Two neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are able to produce a long-lasting enhancement of synaptic transmission in the hippocampus. Unlike other forms of plasticity, neurotrophin-induced plasticity exhibited an immediate requirement for protein synthesis. Plasticity in rat hippocampal slices in which the synaptic neuropil was isolated from the principal cell bodies also required early protein synthesis. Thus, the neurotrophins may stimulate the synthesis of proteins in either axonal or dendritic compartments, allowing synapses to exert local control over the complement of proteins expressed at individual synaptic sites.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.273.5280.1402 DOIArticle
http://www.sciencemag.org/content/273/5280/1402PublisherArticle
http://www.jstor.org/stable/2891422JSTORArticle
Additional Information:© 1996 American Association for the Advancement of Science. 20 May 1996; accepted 16 July 1996. We thank J. Miller and Amgen for supplying BDNF and NT-3, and Caltech faculty and the Schuman lab for helpful discussions and comments. Supported by funds from the Sloan Foundation, John Merck Fund, and Pew Charitable Trusts to E.M.S.
Funders:
Funding AgencyGrant Number
Alfred P. Sloan FoundationUNSPECIFIED
John Merck FundUNSPECIFIED
Pew Charitable Trust UNSPECIFIED
Issue or Number:5280
Record Number:CaltechAUTHORS:20150123-093647592
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150123-093647592
Official Citation:Kang, H., & Schuman, E. M. (1996). A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity. Science, 273(5280), 1402-1406. doi: 10.1126/science.273.5280.1402
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54014
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:23 Jan 2015 20:06
Last Modified:03 Oct 2019 07:54

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