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Immunomicrospheres: reagents for cell labeling and separation

Rembaum, A. and Dreyer, W. J. (1980) Immunomicrospheres: reagents for cell labeling and separation. Science, 208 (4442). pp. 364-368. ISSN 0036-8075. doi:10.1126/science.6768131.

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Immunomicrospheres are specially designed microscopic particles that have antibodies or similar molecules chemically bound to their surfaces. The antibody-coated microspheres react in a highly specific way with target cells, viruses, or other antigenic agents. Immunomicropheres may be synthesized so that they incorporate compounds that are highly radioactive, intensely fluorescent, magnetic, electron opaque, highly colored, or pharmacologically active. These various types of microspheres may be coated with pure, highly specific monoclonal antibodies obtained by the new hybridoma cell cloning techniques or with conventional antibody preparations. Some of the many present and potential applications for these new reagents are (i) new types of radioimmune or immunofluorescent assays, (ii) improved fluorescence microscopy, (iii) separation of cells on the basis of the fluorescent, electrophoretic, or magnetic properties of bound immunomicrospheres, (iv) markers for use in several types of electron or standard light microscopy, and (v) delivery of lethal compounds to specific undesirable living cells. The combination of the various new types of synthetic microspheres and the newly available homogeneous antibodies offers new opportunities in research, diagnosis, and therapy.

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Additional Information:© 1980 American Association for the Advancement of Science. This article represents one phase of research carried out by the Jet Propulsion Laboratory, California Institute of Technology, under NASA contract NAS7-100 sponsored by the National Aeronautics and Space Administration and by NIH grants 1R01CA20668, GM06965, and AI14059.
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Issue or Number:4442
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Official Citation:Rembaum, A., & Dreyer, W. (1980). Immunomicrospheres: reagents for cell labeling and separation. Science, 208(4442), 364-368. doi: 10.1126/science.6768131
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54035
Deposited On:23 Jan 2015 23:33
Last Modified:10 Nov 2021 20:26

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