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Physical properties of artificial extracellular matrix protein films prepared by isocyanate crosslinking

Nowatzki, Paul J. and Tirrell, David A. (2004) Physical properties of artificial extracellular matrix protein films prepared by isocyanate crosslinking. Biomaterials, 25 (7-8). pp. 1261-1267. ISSN 0142-9612. doi:10.1016/S0142-9612(03)00635-5.

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Artificial extracellular matrix proteins, genetically engineered from elastin- and fibronectin-derived repeating units, were crosslinked with hexamethylene diisocyanate in dimethylsulfoxide. The resulting hydrogel films were transparent, uniform, and highly extensible. Their tensile moduli depended on crosslinker concentration and spanned the range characteristic of native elastin. The water content of the films was low (∼27%), but the temperature-dependent swelling behavior of the crosslinked materials was reminiscent of the lower critical solution temperature property of the soluble polymers.

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Tirrell, David A.0000-0003-3175-4596
Additional Information:© 2003 Elsevier Ltd. Received 4 June 2003; accepted 25 July 2003. Published in issue: Volume 25, Issues 7–8, March–April 2004, Pages 1261–1267. Acknowledgments: This work was supported by the National Institutes of Health (R01-HL59987) and the National Science Foundation (BES-9901648).
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Subject Keywords:Cross-linking; Hydrogel; Elastin; Fibronectin; Arterial tissue engineering; Vascular grafts
Issue or Number:7-8
Record Number:CaltechAUTHORS:20150123-161424688
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54040
Deposited By: Katherine Johnson
Deposited On:24 Jan 2015 00:19
Last Modified:10 Nov 2021 20:26

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