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Participation of the protein G_o in multiple aspects of behavior in C. elegans

Mendel, Jane E. and Korswagen, Hendrik C. and Liu, Katharine S. and Hajdu-Cronin, Yvonne M. and Simon, Melvin I. and Plasterk, Ronald H. A. and Sternberg, Paul W. (1995) Participation of the protein G_o in multiple aspects of behavior in C. elegans. Science, 267 (5204). pp. 1652-1655. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150126-093856927

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Abstract

The goa-1 gene encoding the alpha subunit of the heterotrimeric guanosine triphosphatebinding protein (G protein) G_o. from Caenorhabditis elegans is expressed in most neurons, and in the muscles involved in egg laying and male mating. Reduction-of-function mutations in goa-1 caused a variety of behavioral defects including hyperactive movement, premature egg laying, and male impotence. Expression of the activated G_o alpha subunit (Gα_o) in transgenic nematodes resulted in lethargic movement, delayed egg laying, and reduced mating efficiency. Induced expression of activated Gα_o in adults was sufficient to cause these phenotypes, indicating that Gα_o mediates behavior through its role in neuronal function and the functioning of specialized muscles.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.7886455 DOIArticle
http://www.jstor.org/stable/2886749 JSTORArticle
http://www.sciencemag.org/content/267/5204/1652PublisherArticle
ORCID:
AuthorORCID
Sternberg, Paul W.0000-0002-7699-0173
Alternate Title:Participation of the protein Go in multiple aspects of behavior in C. elegans
Additional Information:© 1995 American Association for the Advancement of Science. 8 October 1994; accepted 19 January 1995. We thank S. Gharib for technical assistance and members of our laboratories for critical reading of the manuscript. Some strains were from the Caenorhabditis Genetics Center. Supported by a grant from the Human Frontier Science Program to M.I.S., R.H.A.P., and P.W.S., and by the Howard Hughes Medical Institute of which P.W.S. is an investigator.
Funders:
Funding AgencyGrant Number
Human Frontier Science ProgramUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:5204
Record Number:CaltechAUTHORS:20150126-093856927
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150126-093856927
Official Citation:Mendel, J. E., Korswagen, H. C., Liu, K. S., Hajdu-Cronin, Y. M., Simon, M. I., Plasterk, R. H. A., & Sternberg, P. W. (1995). Participation of the Protein Go in Multiple Aspects of Behavior in C. elegans. Science, 267(5204), 1652-1655. doi: 10.2307/2886749
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54065
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:26 Jan 2015 21:38
Last Modified:03 Mar 2020 13:01

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