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Reciprocal effects of hyper- and hypoactivity mutations in the Drosophila pattern gene torso

Strecker, Teresa R. and Halsell, Susan R. and Fisher, William W. and Lipshitz, Howard D. (1989) Reciprocal effects of hyper- and hypoactivity mutations in the Drosophila pattern gene torso. Science, 243 (4894). pp. 1062-1066. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20150128-112341106

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Abstract

In Drosophila, five "terminal" polarity genes must be active in females in order for them to produce embryos with normal anterior and posterior ends. Hypoactivity mutations in one such gene, torso, result in the loss of the most posterior domain of fushi tarazu expression and the terminal cuticular structures. In contrast, a torso hyperactivity mutation causes the loss of central fushi tarazu expression and central cuticular structures. Cytoplasmic leakage, transplantation, and temperature-shift experiments suggest that the latter effect is caused by abnormal persistence of the torso product in the central region of the embryo during early development. Thus, the amount and timing of torso activity is key to distinguishing the central and terminal regions of the embryo. Mutations in the tailless terminal gene act as dominant maternal suppressors of the hyperactive torso allele, indicating that the torso product acts through, or in concert with, the tailless product.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.2922596DOIArticle
http://www.sciencemag.org/content/243/4894/1062PublisherArticle
http://www.jstor.org/stable/1702977JSTORArticle
Additional Information:© 1989 American Association for the Advancement of Science. 29 August 1988; Accepted 29 November 1988. We thank T. Schüpbach for providing the tor^(splc) allele, for communicating unpublished data, and for helpful discussions. We thank E. B. Lewis for providing Dp(2;3)P32, M. Ashburner for Df(2R)CA58, and J. Topol, C. Dearolf, and C. Parker for providing the ftz-β-gal EΔ-669 transformed line. P. Sternberg, S. Lewis, and D. Mathog provided critical comments on the manuscript. T.R.S. is supported by a junior postdoctoral fellowship from the American Cancer Society (California Division), S.R.H. by a predoctoral traineeship from the NIH, USPHS GM07616. This research was funded by USPHS research grant HD23099 to H.D.L.
Funders:
Funding AgencyGrant Number
American Cancer SocietyUNSPECIFIED
NIHGM07616
U. S. Public Health Service (USPHS)HD23099
Record Number:CaltechAUTHORS:20150128-112341106
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150128-112341106
Official Citation:Strecker, T., Halsell, Fisher, W., & Lipshitz, H. (1989). Reciprocal effects of hyper- and hypoactivity mutations in the Drosophila pattern gene torso. Science, 243(4894), 1062-1066. doi: 10.1126/science.2922596
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ID Code:54186
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:28 Jan 2015 20:23
Last Modified:28 Jan 2015 20:23

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