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Molecular Genetics of the Bithorax Complex in Drosophila melanogaster

Bender, Welcome and Akam, Michael and Karch, François and Beachy, Philip A. and Peifer, Mark and Spierer, Pierre and Lewis, E. B. and Hogness, David S. (1983) Molecular Genetics of the Bithorax Complex in Drosophila melanogaster. Science, 221 (4605). pp. 23-29. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150129-085516108

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Abstract

The bithorax complex in Drosophila melanogaster is a cluster of homeotic genes that specify developmental pathways for many of the body segments of the fly. The DNA of the bithorax complex has been isolated, and a region of 195,000 base pairs that covers the left half of the complex is described here. The lesions associated with many of the bithorax complex mutants have been identified, and most are due to DNA rearrangements. Most of the spontaneous mutants have insertions of a particular mobile element named "gypsy." This element affects the functions of sequences removed from the site of insertion. Mutant lesions for a given phenotypic class are distributed over large DNA distances of up to 73,000 base pairs.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.221.4605.23DOIArticle
http://www.sciencemag.org/content/221/4605/23DOIArticle
http://www.jstor.org/stable/1691427JSTORArticle
Additional Information:© 1983 American Association for the Advancement of Science. 17 March 1983; Revised 11 May 1983. We thank R. Saint for providing subclones of many bithorax restriction fragments., R. Paro for providing clones from the TE77 insertion site, K. Wepsic for care of mutant stocks, and W. Harpain for his generous gift of half-pint milk bottles. This work was supported by NIH grants to W.B., D.S.H., and E.B.L. and by an NSF grant to D.S.H. with additional funding from a Helen Hay Whitney Foundation fellowship (W.B.), a Damon Runyon fellowship (M.A.), Swiss National Foundation fellowships (F.K. and P.S.), and a National Science Foundation predoctoral fellowship (M.P.).
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
NSF Predoctoral FellowshipUNSPECIFIED
Helen Hay Whitney FoundationUNSPECIFIED
Damon Runyon Cancer Research FoundationUNSPECIFIED
Swiss National FoundationUNSPECIFIED
Issue or Number:4605
Record Number:CaltechAUTHORS:20150129-085516108
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150129-085516108
Official Citation:Bender, W., Akam, M., Karch, F., Beachy, P. A., Peifer, M., Spierer, P., . . . Hogness, D. S. (1983). Molecular Genetics of the Bithorax Complex in Drosophila melanogaster. Science, 221(4605), 23-29. doi: 10.1126/science.221.4605.23
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54219
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:29 Jan 2015 21:22
Last Modified:03 Oct 2019 07:56

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