CaltechAUTHORS
  A Caltech Library Service

Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas

Crews, Stephen and Barth, Richard and Hood, Leroy and Prehn, John and Calame, Kathryn (1982) Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas. Science, 218 (4579). pp. 1319-1321. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20150129-123414091

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20150129-123414091

Abstract

Hybridization studies with viral oncogene probes indicate that c-myc, the cellular gene homologous to the transforming gene of avian myelocytomatosis virus, resides on mouse chromosome 15 and in many plasmacytomas is translocated to the antibody heavy chain gene locus on chromosome 12. The transcriptional orientation of the translocated c-myc sequence is opposite the orientation of the adjacent C alpha gene that codes for the heavy chain of immunoglobulin A. The translocated c-myc sequence is not the same oncogene detected in urine plasmacytomas by the NIH-3T3 cell transformation assay.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.7146913DOIArticle
http://www.sciencemag.org/content/218/4579/1319PublisherArticle
http://www.jstor.org/stable/1690204JSTORArticle
Additional Information:© 1982 American Association for the Advancement of Science. Submitted 21 October 1982. Published 24 December 1982. We thank M. Lane and G. Cooper for providing the S107/NIH-3T3 transformed cell lines and S. Aaronson, J.M. Bishop, M. Cline, and D. Slamon for providing cloned oncogenes. Supported by NIH grants (L.H. and K.C.) and by postdoctoral fellowship from the Anna Fuller Fund (R.B.).
Funders:
Funding AgencyGrant Number
National Institutes of Health (NIH)UNSPECIFIED
Anna Fuller FundUNSPECIFIED
Record Number:CaltechAUTHORS:20150129-123414091
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150129-123414091
Official Citation:Crews, S., Barth, R., Hood, L., Prehn, J., & Calame, K. (1982). Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas. Science, 218(4579), 1319-1321. doi: 10.1126/science.7146913
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54230
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:30 Jan 2015 02:18
Last Modified:30 Jan 2015 02:18

Repository Staff Only: item control page