Crews, Stephen and Barth, Richard and Hood, Leroy and Prehn, John and Calame, Kathryn (1982) Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas. Science, 218 (4579). pp. 1319-1321. ISSN 0036-8075. doi:10.1126/science.7146913. https://resolver.caltech.edu/CaltechAUTHORS:20150129-123414091
Full text is not posted in this repository. Consult Related URLs below.
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20150129-123414091
Abstract
Hybridization studies with viral oncogene probes indicate that c-myc, the cellular gene homologous to the transforming gene of avian myelocytomatosis virus, resides on mouse chromosome 15 and in many plasmacytomas is translocated to the antibody heavy chain gene locus on chromosome 12. The transcriptional orientation of the translocated c-myc sequence is opposite the orientation of the adjacent C alpha gene that codes for the heavy chain of immunoglobulin A. The translocated c-myc sequence is not the same oncogene detected in urine plasmacytomas by the NIH-3T3 cell transformation assay.
| Item Type: | Article | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Related URLs: |
| ||||||||||||
| ORCID: |
| ||||||||||||
| Additional Information: | © 1982 American Association for the Advancement of Science. Submitted 21 October 1982. Published 24 December 1982. We thank M. Lane and G. Cooper for providing the S107/NIH-3T3 transformed cell lines and S. Aaronson, J.M. Bishop, M. Cline, and D. Slamon for providing cloned oncogenes. Supported by NIH grants (L.H. and K.C.) and by postdoctoral fellowship from the Anna Fuller Fund (R.B.). | ||||||||||||
| Funders: |
| ||||||||||||
| Issue or Number: | 4579 | ||||||||||||
| DOI: | 10.1126/science.7146913 | ||||||||||||
| Record Number: | CaltechAUTHORS:20150129-123414091 | ||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150129-123414091 | ||||||||||||
| Official Citation: | Crews, S., Barth, R., Hood, L., Prehn, J., & Calame, K. (1982). Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas. Science, 218(4579), 1319-1321. doi: 10.1126/science.7146913 | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 54230 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | INVALID USER | ||||||||||||
| Deposited On: | 30 Jan 2015 02:18 | ||||||||||||
| Last Modified: | 10 Nov 2021 20:30 |
Repository Staff Only: item control page
