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Inertial Imaging with Nanomechanical Systems

Hanay, M. Selim and Kelber, Scott I. and O’Connell, Cathal D. and Mulvaney, Paul and Sader, John E. and Roukes, Michael L. (2015) Inertial Imaging with Nanomechanical Systems. Nature Nanotechnology, 10 (4). pp. 339-344. ISSN 1748-3387. PMCID PMC5283574. doi:10.1038/nnano.2015.32.

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Mass sensing with nanoelectromechanical systems has advanced significantly during the last decade. With nanoelectromechanical systems sensors it is now possible to carry out ultrasensitive detection of gaseous analytes, to achieve atomic-scale mass resolution and to perform mass spectrometry on single proteins. Here, we demonstrate that the spatial distribution of mass within an individual analyte can be imaged—in real time and at the molecular scale—when it adsorbs onto a nanomechanical resonator. Each single-molecule adsorption event induces discrete, time-correlated perturbations to all modal frequencies of the device. We show that by continuously monitoring a multiplicity of vibrational modes, the spatial moments of mass distribution can be deduced for individual analytes, one-by-one, as they adsorb. We validate this method for inertial imaging, using both experimental measurements of multimode frequency shifts and numerical simulations, to analyse the inertial mass, position of adsorption and the size and shape of individual analytes. Unlike conventional imaging, the minimum analyte size detectable through nanomechanical inertial imaging is not limited by wavelength-dependent diffraction phenomena. Instead, frequency fluctuation processes determine the ultimate attainable resolution. Advanced nanoelectromechanical devices appear capable of resolving molecular-scale analytes.

Item Type:Article
Related URLs:
URLURL TypeDescription ReadCube access CentralArticle
Hanay, M. Selim0000-0002-1928-044X
Kelber, Scott I.0000-0001-5906-3506
O’Connell, Cathal D.0000-0002-1690-9505
Mulvaney, Paul0000-0002-8007-3247
Sader, John E.0000-0002-7096-0627
Roukes, Michael L.0000-0002-2916-6026
Additional Information:© 2015 Macmillan Publishers Limited. Received 24 August 2014; Accepted 06 February 2015; Published online 30 March 2015. The authors acknowledge support from an NIH Director’s Pioneer award (to M.L.R.), a Caltech Kavli Nanoscience Institute Distinguished Visiting Professorship (to J.E.S.), the Fondation pour la Recherche et l’Enseignement Superieur, Paris (FRES; to M.L.R.), and the Australian Research Council grants scheme (P.M. and J.E.S.). Author contributions: M.L.R. and J.E.S. supervised the project. J.E.S. provided the principal mathematical idea for mass measurement using mode superposition that was extended to imaging by M.L.R. The resulting theory was further developed by M.S.H., S.I.K., J.E.S., and M.L.R. Droplet measurements were conceived by J.E.S., performed by C.D.O., and supervised by P.M. and J.E.S. The paper was written by M.S.H., S.I.K., C.D.O., J.E.S., and M.L.R. The FE simulations were executed by M.S.H. and S.I.K. All authors analysed the data and contributed to the writing of the paper.
Group:Kavli Nanoscience Institute
Funding AgencyGrant Number
NIH Director’s Pioneer AwardUNSPECIFIED
Kavli Nanoscience InstituteUNSPECIFIED
Fondation pour la Recherche et l’Enseignement SuperieurUNSPECIFIED
Australian Research CouncilUNSPECIFIED
Issue or Number:4
PubMed Central ID:PMC5283574
Record Number:CaltechAUTHORS:20150131-150355721
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54267
Deposited By: George Porter
Deposited On:06 Apr 2015 15:10
Last Modified:08 Jun 2022 16:40

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