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A common language for physical mapping of the human genome

Olson, Maynard and Hood, Leroy E. and Cantor, Charles R. and Botstein, David (1989) A common language for physical mapping of the human genome. Science, 245 (4925). pp. 1434-1435. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20150204-095632146

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Abstract

In a report issued in January 1988, the National Research Council (NRC) Committee on the Mapping and Sequencing of the Human Genome, on which the present authors served, recommended a staged mapping and sequencing project with early emphases on physical mapping of human DNA, mapping and sequencing of the genomes of model organisms, and the development of sequencing technology (1). As the Committee's recommendations on physical mapping are beginning to be implemented on a substantial scale, it is timely to review these recommendations in the light of recent technical advances. In particular, the polymerase chain reaction (PCR) (2), a method that has only come into widespread use during the past 2 years, seems to us to offer a path toward a physical map that largely circumvents two problems that were prominent in the NRC Committee's discussions. One of these was the difficulty of merging mapping data gathered by diverse methods in different laboratories into a consensus physical map. The second was the logistics and expense of managing the huge collections of cloned segments on which the mapping data would depend almost absolutely.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.2781285 DOIArticle
http://www.sciencemag.org/content/245/4925/1434PublisherArticle
http://www.jstor.org/stable/1704517?origin=JSTOR-pdfJSTORArticle
Additional Information:© 1989 American Association for the Advancement of Science.
Record Number:CaltechAUTHORS:20150204-095632146
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150204-095632146
Official Citation:Olson, M., Hood, L., Cantor, C., & Botstein, D. (1989). A common language for physical mapping of the human genome. Science, 245(4925), 1434-1435. doi: 10.1126/science.2781285
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54364
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:04 Feb 2015 21:46
Last Modified:04 Feb 2015 21:46

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