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Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor

Doolittle, Russell F. and Hunkapiller, Michael W. and Hood, Leroy E. and Devare, Sushilkumar G. and Robbins, Keith C. and Aaronson, Stuart A. and Antoniades, Harry N. (1983) Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science, 221 (4607). pp. 275-277. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150204-123903511

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Abstract

The transforming protein of a primate sarcoma virus and a platelet-derived growth factor are derived from the same or closely related cellular genes. This conclusion is based on the demonstration of extensive sequence similarity between the transforming protein derived from the simian sarcoma virus onc gene, v-sis, and a human platelet-derived growth factor. The mechanism by which v-sis transforms cells could involve the constitutive expression of a protein with functions similar or identical to those of a factor active transiently during normal cell growth.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.6304883DOIArticle
http://www.sciencemag.org/content/221/4607/275PublisherArticle
http://www.jstor.org/stable/1691119JSTORArticle
Additional Information:© 1983 American Association for the Advancement of Science. 3 June 1983; Revised 12 June 1983. We thank T. Hunkapiller for preparation of Fig. 1, and the American Red Cross Blood Services, Northeast Section, for the supply of clinically outdated human platelets. Supported in part by NIH research grants RR00757 (R.F.D.) and CA30101 (H.N.A.) and by grants from the Council for Tobacco Research, USA, Inc. (H.N.A.) and the Weingart Foundation (L.E.H.).
Funders:
Funding AgencyGrant Number
NIHRR00757
NIHCA30101
Council for Tobacco ResearchUNSPECIFIED
Weingart FoundationUNSPECIFIED
Issue or Number:4607
Record Number:CaltechAUTHORS:20150204-123903511
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150204-123903511
Official Citation:Doolittle, R., Hunkapiller, M., Hood, L., Devare, S., Robbins, K., Aaronson, S., & Antoniades, H. (1983). Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science, 221(4607), 275-277. doi: 10.1126/science.6304883
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54374
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:05 Feb 2015 22:53
Last Modified:03 Oct 2019 07:57

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