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Human Platelet-Derived Growth Factor (PDGF): Amino-Terminal Amino Acid Sequence

Antoniades, Harry N. and Hunkapiller, Michael W. (1983) Human Platelet-Derived Growth Factor (PDGF): Amino-Terminal Amino Acid Sequence. Science, 220 (4600). pp. 963-965. ISSN 0036-8075. doi:10.1126/science.6844921.

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Human platelet-derived growth factor (PDGF) obtained from outdated human platelets was subjected to amino-terminal amino acid sequence analysis by automated Edman degradation. Despite the apparent presence of limited proteolytic degradation of the protein derived from this method, the sequence analysis reveals two primary peptide sequences and suggests that active PDGF is composed of two, possibly homologous, peptides linked by a disulfide bond or bonds.

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Additional Information:© 1983 American Association for the Advancement of Science. 5 January 1983; revised 17 March 1983. Supported by the Weingart Foundation, National Cancer Institute grant CA30101, and a grant from the Council for Tobacco Research, USA, Inc. We thank P. Moran, R. Siraco, and K. Burke-Howie for assistance in purification and cell culture assays of PDGF and the American Red Cross Blood Services, Northeast Region, for the supply of clinically outdated human platelets.
Funding AgencyGrant Number
Weingart FoundationUNSPECIFIED
National Cancer InstituteCA30101
Council for Tobacco ResearchUNSPECIFIED
Issue or Number:4600
Record Number:CaltechAUTHORS:20150205-090218284
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Official Citation:Human platelet-derived growth factor (PDGF): amino-terminal amino acid sequence HN Antoniades and MW Hunkapiller Science 27 May 1983: 220 (4600), 963-965. [DOI:10.1126/science.6844921]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54408
Deposited On:05 Feb 2015 17:25
Last Modified:10 Nov 2021 20:33

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