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Nucleotide Sequence of a Light Chain Gene of the Mouse I-A Subregion: Aβ^d

Malissen, Marie and Hunkapiller, Tim and Hood, Leroy (1983) Nucleotide Sequence of a Light Chain Gene of the Mouse I-A Subregion: Aβ^d. Science, 221 (4612). pp. 750-754. ISSN 0036-8075. doi:10.1126/science.6410508.

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Iɑ (I region-associated) antigens are cell-surface glycoproteins involved in the regulation of immune responsiveness. They are composed of one heavy (ɑ) and one light (β) polypeptide chain. We have sequenced the gene encoding the Aβ^d chain of the BALB/c mouse. The presence of six exons is predicted by comparison with the complementary DNA sequences of human β chains and with partial protein sequence data for the Aβ^d polypeptide. Sequence comparisons have been made to other proteins involved in immune responses and the consequent implications for the evolutionary relationships of these genes are discussed.

Item Type:Article
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Hood, Leroy0000-0001-7158-3678
Additional Information:© 1983 American Association for the Advancement of Science. 16 June 1983. We thank M. Steinmetz for his help during the initiation of this work, K. Minard for preparation of the sequencing gels, and B. Larsh and S. Olive for preparation of the manuscript. Supported in part by NIH grants (L.H.) and by the Fondation pour la Recherche Medicale (M.M.).
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Fondation pour la Recherche MedicaleUNSPECIFIED
Issue or Number:4612
Record Number:CaltechAUTHORS:20150205-092627258
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Official Citation:Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d M Malissen, T Hunkapiller, and L Hood Science 19 August 1983: 221 (4612), 750-754. [DOI:10.1126/science.6410508]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54410
Deposited On:05 Feb 2015 23:05
Last Modified:10 Nov 2021 20:33

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