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Nucleotide Sequence of a Light Chain Gene of the Mouse I-A Subregion: Aβ^d

Malissen, Marie and Hunkapiller, Tim and Hood, Leroy (1983) Nucleotide Sequence of a Light Chain Gene of the Mouse I-A Subregion: Aβ^d. Science, 221 (4612). pp. 750-754. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150205-092627258

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Abstract

Iɑ (I region-associated) antigens are cell-surface glycoproteins involved in the regulation of immune responsiveness. They are composed of one heavy (ɑ) and one light (β) polypeptide chain. We have sequenced the gene encoding the Aβ^d chain of the BALB/c mouse. The presence of six exons is predicted by comparison with the complementary DNA sequences of human β chains and with partial protein sequence data for the Aβ^d polypeptide. Sequence comparisons have been made to other proteins involved in immune responses and the consequent implications for the evolutionary relationships of these genes are discussed.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.6410508DOIArticle
http://www.sciencemag.org/content/221/4612/750.abstractPublisherArticle
http://www.jstor.org/stable/1691029JSTORArticle
Additional Information:© 1983 American Association for the Advancement of Science. 16 June 1983. We thank M. Steinmetz for his help during the initiation of this work, K. Minard for preparation of the sequencing gels, and B. Larsh and S. Olive for preparation of the manuscript. Supported in part by NIH grants (L.H.) and by the Fondation pour la Recherche Medicale (M.M.).
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Fondation pour la Recherche Medicale UNSPECIFIED
Issue or Number:4612
Record Number:CaltechAUTHORS:20150205-092627258
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150205-092627258
Official Citation:Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d M Malissen, T Hunkapiller, and L Hood Science 19 August 1983: 221 (4612), 750-754. [DOI:10.1126/science.6410508]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54410
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:05 Feb 2015 23:05
Last Modified:03 Oct 2019 07:57

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