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A Micromechanical Contribution to Cochlear Tuning and Tonotopic Organization

Holton, Thomas and Hudspeth, A. J. (1983) A Micromechanical Contribution to Cochlear Tuning and Tonotopic Organization. Science, 222 (4623). pp. 508-510. ISSN 0036-8075. doi:10.1126/science.6623089.

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The response properties of hair cells and nerve fibers in the alligator lizard cochlea are frequency selective and tonotopically organized with longitudinal position in the organ. The lengths of the hair-cell hair bundles also vary monotonically with longitudinal position. In this study, quantitative measurements were made of the motion of individual hair bundles in an excised preparation of the cochlea stimulated at auditory frequencies. The angular displacement of hair bundles is frequency selective and tonotopically organized, demonstrating the existence of a micromechanical tuning mechanism.

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Additional Information:© 1983 American Association for the Advancement of Science. 28 February 1983; accepted 25 July 1983. Supported by fellowships to T.H. from the Del E. Webb Foundation and the National Institutes of Health (GM07301) and grants to A.J.H. from NIH (NSl3l54) and the System Development Foundation. We thank J. N. Power for electronic design and construction, R. Jacobs for technical assistance, and H. Berg, R. A. Eatock, M. Konishi, R. S. Lewis, and D. C. Van Essen for comments on the manuscript.
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Del E. Webb FoundationUNSPECIFIED
System Development FoundationUNSPECIFIED
Issue or Number:4623
Record Number:CaltechAUTHORS:20150205-095841191
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Official Citation:A micromechanical contribution to cochlear tuning and tonotopic organization T Holton and AJ Hudspeth Science 4 November 1983: 222 (4623), 508-510. [DOI:10.1126/science.6623089]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54414
Deposited On:05 Feb 2015 23:03
Last Modified:10 Nov 2021 20:33

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