A Caltech Library Service

Nitrogenase and Biological Nitrogen Fixation

Kim, Jongsun and Rees, Douglas C. (1994) Nitrogenase and Biological Nitrogen Fixation. Biochemistry, 33 (2). pp. 389-397. ISSN 0006-2960.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Biological nitrogen fixation is catalyzed by the nitrogenase enzyme system which consists of two metalloproteins, the iron (Fe-) protein and the molybdenum-iron (MoFe-) protein. Together, these proteins mediate the ATP-dependent reduction of dinitrogen to ammonia. Recent crystallographic analyses of Fe-protein and MoFe-protein have revealed the polypeptide fold and the structure and organization of the unusual metal centers in nitrogenase. These structure provide a molecular framework for addressing the mechanism of the nitrogenase-catalyzed reaction. General features of the nitrogenase system, including conformational coupling of nucleotide hydrolysis, aspects of the cluster structures, and the general spatial organization of redox centers within the protein subunits, are relevant to a wide range of biochemical systems.

Item Type:Article
Related URLs:
URLURL TypeDescription DOIArticle
Rees, Douglas C.0000-0003-4073-1185
Contact Email
Additional Information:© 1994 American Chemical Society. Received September 28, 1993; Revised Manuscript Received November 12, 1993. Work in the authors' lab was supported by USPHS Grant GM45162 (Fe-protein) and NSF Grant DMB 91-18689 (MoFe-protein). The invaluable contributions of B. T. Hsu, M.M. Georgiadis, D. Woo, M.W. Day, M.K. Chan, H. Komiya, J.L. Schlessman, L. Joshua-Tor, A.J. Chirino, and M.H.B. Stowell to various phases of this project are deeply appreciated, as are numerous discussions with J.B. Howard.
Funding AgencyGrant Number
U.S. Public Health ServiceGM45162
NSFDMB 91-18689
Issue or Number:2
Record Number:CaltechAUTHORS:20150205-141446723
Persistent URL:
Official Citation:Nitrogenase and biological nitrogen fixation Jongsun Kim and Douglas C. Rees Biochemistry 1994 33 (2), 389-397
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54448
Deposited By: SWORD User
Deposited On:08 Feb 2015 02:47
Last Modified:03 Oct 2019 07:57

Repository Staff Only: item control page