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Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution

Rice, Charles M. and Lenches, Edith M. and Eddy, Sean R. and Shin, Se Jung and Sheets, Rebecca L. and Strauss, James H. (1985) Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science, 229 (4715). pp. 726-733. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20150205-145444154

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Abstract

The sequence of the entire RNA genome of the type flavivirus, yellow fever virus, has been obtained. Inspection of this sequence reveals a single long open reading frame of 10,233 nucleotides, which could encode a polypeptide of 3411 amino acids. The structural proteins are found within the amino-terminal 780 residues of this polyprotein; the remainder of the open reading frame consists of nonstructural viral polypeptides. This genome organization implies that mature viral proteins are produced by posttranslational cleavage of a polyprotein precursor and has implications for flavivirus RNA replication and for the evolutionary relation of this virus family to other RNA viruses.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.4023707DOIArticle
http://www.sciencemag.org/content/229/4715/726PublisherArticle
http://www.jstor.org/stable/1696098JSTORArticle
Additional Information:© 1985 American Association for the Advancement of Science. 17 May 1985; Accepted 7 July 1985. We thank E. G. Strauss, L. Dalgarno, and C. Chang for helpful discussions and our many colleagues for critical comments on the manuscript; L. Hood and T. Hunkapiller for the use of their computer facilities; and C. S. Hahn for help with RNA secondary structure analysis. We also thank G. Cleaves, J. J . Schlesinger, and F. X. Heinz for allowing us to quote their unpublished results. Supported in part by grants AI 20612 and AI 10793 from NIH and by grant PCM 83-16856 from NSF.
Funders:
Funding AgencyGrant Number
NIHAI 20612
NIHAI 10793
NSFPCM 83-16856
Record Number:CaltechAUTHORS:20150205-145444154
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150205-145444154
Official Citation:Rice, C. M., Lenches, E. M., Eddy, Shin, S. J., Sheets, R. L., & Strauss, J. H. (1985). Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science, 229(4715), 726-733.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54461
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:05 Feb 2015 23:14
Last Modified:05 Feb 2015 23:14

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