Rice, Charles M. and Lenches, Edith M. and Eddy, Sean R. and Shin, Se Jung and Sheets, Rebecca L. and Strauss, James H. (1985) Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science, 229 (4715). pp. 726-733. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150205-145444154
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Abstract
The sequence of the entire RNA genome of the type flavivirus, yellow fever virus, has been obtained. Inspection of this sequence reveals a single long open reading frame of 10,233 nucleotides, which could encode a polypeptide of 3411 amino acids. The structural proteins are found within the amino-terminal 780 residues of this polyprotein; the remainder of the open reading frame consists of nonstructural viral polypeptides. This genome organization implies that mature viral proteins are produced by posttranslational cleavage of a polyprotein precursor and has implications for flavivirus RNA replication and for the evolutionary relation of this virus family to other RNA viruses.
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| Additional Information: | © 1985 American Association for the Advancement of Science. 17 May 1985; Accepted 7 July 1985. We thank E. G. Strauss, L. Dalgarno, and C. Chang for helpful discussions and our many colleagues for critical comments on the manuscript; L. Hood and T. Hunkapiller for the use of their computer facilities; and C. S. Hahn for help with RNA secondary structure analysis. We also thank G. Cleaves, J. J . Schlesinger, and F. X. Heinz for allowing us to quote their unpublished results. Supported in part by grants AI 20612 and AI 10793 from NIH and by grant PCM 83-16856 from NSF. | ||||||||||||
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| Issue or Number: | 4715 | ||||||||||||
| Record Number: | CaltechAUTHORS:20150205-145444154 | ||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150205-145444154 | ||||||||||||
| Official Citation: | Rice, C. M., Lenches, E. M., Eddy, Shin, S. J., Sheets, R. L., & Strauss, J. H. (1985). Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science, 229(4715), 726-733. | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 54461 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | Joanne McCole | ||||||||||||
| Deposited On: | 05 Feb 2015 23:14 | ||||||||||||
| Last Modified: | 03 Oct 2019 07:58 |
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